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Case Reports
. 2020 Mar 19;7(3):e00344.
doi: 10.14309/crj.0000000000000344. eCollection 2020 Mar.

Eosinophilic Enterocolitis: Gastric Outlet Obstruction

Shana Kothari  1 , Imad Elkhatib  2
Affiliations
Case Reports

Eosinophilic Enterocolitis: Gastric Outlet Obstruction

Shana Kothari et al. ACG Case Rep J. .

Abstract

Eosinophilic enterocolitis is a rare condition representing the least frequent manifestation of eosinophilic gastrointestinal disorders. We report a 49-year-old man who presented with abdominal pain, diarrhea, and intractable vomiting for 2 weeks. Abdominal computed tomography demonstrated gastric wall thickening with mural wall thickening of the small intestine and colon. Endoscopy revealed gastric outlet obstruction because of luminal stenosis from duodenal edema. Peripheral eosinophilia, endoscopic mucosal biopsies, and exclusion of differential diagnoses confirmed eosinophilic enterocolitis. The patient was successfully treated with a 4-week prednisone taper.

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Figures

Figure 1.
Figure 1.
Axial abdominal computed tomography with contrast shows moderately distended stomach with moderate thickening of the wall of the stomach concerning gastric outlet obstruction.
Figure 2.
Figure 2.
Coronal abdominal computed tomography with contrast shows moderate thickening of the small bowel and marked thickening of the duodenum and proximal jejunum.
Figure 3.
Figure 3.
Endoscopic image of the duodenal edema and erythema with luminal stenosis.
Figure 4.
Figure 4.
Biopsy of the left colon showing areas of markedly increased eosinophilic infiltration (400× magnification).
See this image and copyright information in PMC

References

    1. Samiullah N, Bhurgri H, Sohail U. Eosinophilic disorders of the gastrointestinal tract. Prim Care. 2016;43:495–504. - PubMed
    1. Alfadda AA, Storr MA, Shaffer EA. Eosinophilic colitis: Epidemiology, clinical features, and current management. Therap Adv Gastroenterol. 2011;4:301–9. - PMC - PubMed
    1. Guajardo JR, Plotnick LM, Fende JM, Collins MH, Putnam PE, Rothenberg ME. Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry. J Pediatr. 2002;141(4):576–81. - PubMed
    1. Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR. Eosinophilic gastroenteritis: A clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut. 1990;31(1):54–8. - PMC - PubMed
    1. Fulkerson PC, Rothenberg ME. Targeting eosinophils in allergy, inflammation and beyond. Nat Rev Drug Discov. 2013;12(2):117–29. - PMC - PubMed

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