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. 2020 Aug;35(8):1471-1475.
doi: 10.1007/s00467-020-04559-7. Epub 2020 Apr 27.

Delayed menarche in girls with chronic kidney disease and the association with short stature

Hannah S Kim  1 , Derek K Ng  2 , Matthew B Matheson  2 , Meredith A Atkinson  3 , Bradley A Warady  4 , Susan L Furth  5 , Rebecca L Ruebner  3
Affiliations

Delayed menarche in girls with chronic kidney disease and the association with short stature

Hannah S Kim et al. Pediatr Nephrol. 2020 Aug.

Abstract

Background: Children with chronic kidney disease (CKD) have delays in normal growth and pubertal development. We describe factors associated with delayed menarche and the association of delayed menarche with short stature in girls with CKD.

Methods: Two hundred eighty-seven girls with CKD onset prior to menarche within the Chronic Kidney Disease in Children (CKiD) cohort were studied. Delayed menarche was defined as menarche at age 15 years or older; short stature was defined as last available height 2 standard deviations below projected adult height. Kaplan-Meier cumulative incidence function was used to estimate median age at menarche. Chi-squared and Wilcoxon rank-sum tests were used to assess factors associated with delayed menarche. Chi-squared test was used to evaluate the association between delayed menarche and short stature.

Results: Among 287 girls, 68 enrolled with prevalent menarche, 131 were observed to have incident menarche, and 88 were pre-menarchal at their last study visit. Median age at menarche was 12 years. Ten percent had delayed menarche. African American race, lower estimated glomerular filtration rate, ever corticosteroid use, and longer CKD duration were associated with delayed menarche (p < 0.05). Girls with delayed menarche had lower height and weight percentiles at the time of menarche (p < 0.05). Sixty-one percent of girls with delayed menarche had short stature compared with only 35% of girls without delayed menarche (p = 0.03).

Conclusion: Median age at menarche is similar among girls with CKD and healthy girls. Ten percent of girls with CKD had delayed menarche and may be at risk for short stature.

Keywords: Chronic kidney disease; Growth; Height; Menarche; Puberty; Short stature.

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Conflict of interest statement

Conflict of Interest: The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.. Cumulative Percentage of Menarche in NHANES versus CKiD
Footnotes * Includes 287 girls
See this image and copyright information in PMC

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