Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project

Affiliations

¹ Department of Clinical Pharmacology and Toxicology, Charité University Medicine, Berlin, Germany.
² Department of Cardiology, University of Oslo, Ullevaal Hospital, Oslo Norway.
³ Service of Nephrology and Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
⁴ Department of Hypertension and Diabetology, Medical University of Gdansk, Poland.
⁵ Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, AL, USA.
⁶ University of Milano-Bicocca, Milan, Italy.

Free article

Editorial

Reinhold Kreutz et al. Blood Press. 2020 Jun.

Free article

. 2020 Jun;29(3):135-136.

doi: 10.1080/08037051.2020.1747696. Epub 2020 Apr 27.

¹ Department of Clinical Pharmacology and Toxicology, Charité University Medicine, Berlin, Germany.
² Department of Cardiology, University of Oslo, Ullevaal Hospital, Oslo Norway.
³ Service of Nephrology and Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
⁴ Department of Hypertension and Diabetology, Medical University of Gdansk, Poland.
⁵ Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, AL, USA.
⁶ University of Milano-Bicocca, Milan, Italy.

No abstract available

Comment on

Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial.
Hermida RC, Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, Ayala DE; Hygia Project Investigators. Hermida RC, et al. Eur Heart J. 2020 Dec 21;41(48):4565-4576. doi: 10.1093/eurheartj/ehz754. Eur Heart J. 2020. PMID: 31641769 Clinical Trial.
Chronotherapy for hypertension: improvement in patient outcomes with bedtime administration of antihypertensive drugs.
Mathur P, Kadavath S, Marsh JD, Mehta JL. Mathur P, et al. Eur Heart J. 2020 Dec 21;41(48):4577-4579. doi: 10.1093/eurheartj/ehz836. Eur Heart J. 2020. PMID: 31723974 No abstract available.