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Comment
. 2020 May 4;219(5):e202003132.
doi: 10.1083/jcb.202003132.

A firehose for phospholipids

William A Prinz  1 , James H Hurley  2   3
Affiliations
Comment

A firehose for phospholipids

William A Prinz et al. J Cell Biol. .

Abstract

All lipid transport proteins in eukaryotes are thought to shuttle lipids between cellular membranes. In this issue, Li et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202001161) show that Vps13 has a channel-like domain that may allow lipids to flow between closely apposed membranes at contact sites.

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Figures

Figure 1.
Figure 1.
Two types of intramembrane lipid transporters. (A) Shuttling transporters move one lipid at a time between membranes. (B) Bridging transporters allow lipids to flow between membranes though a hydrophobic tunnel or conduit.
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Comment on

References

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