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Comment
. 2020 Jun;41(6):384-386.
doi: 10.1016/j.tips.2020.04.002. Epub 2020 Apr 24.

Pharmacological Targeting of the Actin Cytoskeleton to Drive Endocrinogenesis

Johanna Siehler  1 , Anna Karolina Blöchinger  1 , Heiko Lickert  2
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Comment

Pharmacological Targeting of the Actin Cytoskeleton to Drive Endocrinogenesis

Johanna Siehler et al. Trends Pharmacol Sci. 2020 Jun.

Abstract

In vitro generation of insulin-secreting beta cells from human pluripotent stem cells (hPSCs) opens new avenues for treating and modeling diabetes. Hogrebe and colleaguesestablished a new 2D differentiation protocol where they targeted the cytoskeleton pharmacologically for controlled endocrine induction and generation of hPSC-derived beta cells with improved function.

Keywords: Latrunculin A; actin; beta cells; endocrine progenitors; pancreatic progenitors; stem cells.

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