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Review
. 2020 Jun;17(6):316-317.
doi: 10.1038/s41585-020-0325-9.

Could BCG be used to protect against COVID-19?

Gil Redelman-Sidi  1
Affiliations
Review

Could BCG be used to protect against COVID-19?

Gil Redelman-Sidi. Nat Rev Urol. 2020 Jun.

Abstract

Nearly 100 years since it was first used in humans as a vaccine for tuberculosis, Bacillus Calmette–Guérin (BCG) has been suggested as a possible agent to prevent coronavirus disease 2019 (COVID-19). A number of studies are underway to investigate this possibility but — even if they prove effective — many questions will remain.

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Conflict of interest statement

The author declares no competing interests.

Comment in

  • The effect of BCG vaccine in the era of COVID-19 pandemic.
    Abbas AM, AbouBakr A, Bahaa N, Michael S, Ghobrial M, AbuElmagd ME, Ahmed OA, AbdelWahab RA, Shaltout AS. Abbas AM, et al. Scand J Immunol. 2020 Dec;92(6):e12947. doi: 10.1111/sji.12947. Epub 2020 Aug 27. Scand J Immunol. 2020. PMID: 32698247 Free PMC article. No abstract available.

References

    1. Colditz GA, et al. The efficacy of bacillus Calmette-Guerin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature. Pediatrics. 1995;96:29–35. - PubMed
    1. Redelman-Sidi G, Glickman MS, Bochner BH. The mechanism of action of BCG therapy for bladder cancer-a current perspective. Nat. Rev. Urol. 2014;11:153–162. doi: 10.1038/nrurol.2014.15. - DOI - PubMed
    1. Higgins JP, et al. Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review. BMJ. 2016;355:i5170. doi: 10.1136/bmj.i5170. - DOI - PMC - PubMed
    1. Hollm-Delgado MG, Stuart EA, Black RE. Acute lower respiratory infection among Bacille Calmette-Guerin (BCG)-vaccinated children. Pediatrics. 2014;133:e73–e81. doi: 10.1542/peds.2013-2218. - DOI - PubMed
    1. Goodridge HS, et al. Harnessing the beneficial heterologous effects of vaccination. Nat. Rev. Immunol. 2016;16:392–400. doi: 10.1038/nri.2016.43. - DOI - PMC - PubMed

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