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. 2020 Apr 3;7(1):e000396.
doi: 10.1136/lupus-2020-000396. eCollection 2020.

Thoughts on COVID-19 and autoimmune diseases

Anca D Askanase  1 , Leila Khalili  1 , Jill P Buyon  2
Affiliations

Thoughts on COVID-19 and autoimmune diseases

Anca D Askanase et al. Lupus Sci Med. .

Abstract

Over the 2 months since coronavirus first appeared in China, cases have emerged on every continent, and it is clear that patients with autoimmune diseases might also be affected. Coronavirus disease 2019 (COVID-19) is a highly contagious viral illness with a mortality rate approaching 2%. Here we discuss the challenges that patients with autoimmune diseases might face and the information on using immunomodulatory therapies like chloroquine, tocilizumab and baricitinib to quench the cytokine storm in patients with very severe COVID-19 pneumonia.

Keywords: autoimmune diseases; cytokines; inflammation.

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Conflict of interest statement

Competing interests: None declared.

References

    1. World Health Organization Coronavirus disease 2019 (COVID-19) situation report 48, 2020. Available: https://www.who.int/docs/default-source/coronaviruse/situation-reports/2...
    1. Centers for Disease Control and Prevention Coronavirus disease 2019 (COVID-19) in the U.S, 2020. Available: https://www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html#investigation
    1. National Institute of Allergy and Infectious Diseases Coronaviruses, 2020. Available: https://www.niaid.nih.gov/diseases-conditions/coronaviruses
    1. Centers for Disease Control and Prevention Interim clinical guidance for management of patients with confirmed coronavirus disease (COVID-19), 2020. Available: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-manageme...
    1. Zhang W, Du R-H, Li B, et al. . Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect 2020;9:386–9. 10.1080/22221751.2020.1729071 - DOI - PMC - PubMed

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