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Comment
. 2020 Jun 1;152(6):e202012571.
doi: 10.1085/jgp.202012571.

The action of a BK channel opener

Jianmin Cui  1
Affiliations
Comment

The action of a BK channel opener

Jianmin Cui. J Gen Physiol. .

Abstract

Rockman et al. in this issue of JGP describe how NS11021 opens BK channels, which make the compound a better tool to probe physiological roles and gating mechanisms of BK channels.

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Figures

Figure 1.
Figure 1.
BK channel structure and gating mechanisms. (A) Structure of the human BK channel (Protein Database accession no. 6V38; Tao and MacKinnon, 2019). The VSD (green) and PGD (orange) of only two subunits are shown for clarity. Ca2+ ions bound to the CSD (red and blue) are shown as yellow dots. (B) An allosteric gating mechanism (Horrigan and Aldrich, 2002). L, J, and K are equilibrium constants, which are influenced by conformational changes in the GPD, VSD, and CSD domains and interactions among the three domains. D, C, and E are allosteric constants for these interactions.
See this image and copyright information in PMC

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References

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