Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Sep;27(13):1436-1437.
doi: 10.1177/2047487320922370. Epub 2020 Apr 28.

ABO blood group predisposes to COVID-19 severity and cardiovascular diseases

Xiaofeng Dai  1
Affiliations
Review

ABO blood group predisposes to COVID-19 severity and cardiovascular diseases

Xiaofeng Dai. Eur J Prev Cardiol. 2020 Sep.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Conceptual Illustration on the predisposing role of ABO blood type to cardiovascular diseases and COVID-19 severity. Blood O type is protective against the development of cardiovascular diseases and severe COVID-19 as it is associated with lower angiotensin-converting enzyme (ACE) level and higher ACE2 activity. Blood A type is risky for the development of cardiovascular diseases and severe COVID-19 due to: (a) its positive association with ACE activity, and (b) the attachment of adhesion molecules on the vascular wall that increases inflammation and decreases blood circulation.
See this image and copyright information in PMC

Comment in

References

    1. World Health Organization. Coronavirus Disease (COVID-19) Situation Report, Volume 55 Geneva: World Health Organization, 2020.
    1. Dawei W, Bo H, Chang H, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA 2020; 323: 1061–1069. - PMC - PubMed
    1. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. Epub ahead of print 28 February 2020. DOI: 10.1056/NEJMoa2002032. - PMC - PubMed
    1. Ibrahim MM. RAS inhibition in hypertension. J Hum Hypertens 2006; 20: 101–108. - PubMed
    1. Fang Y, Gao F, Liu Z Angiotensin-converting enzyme 2 attenuates inflammatory response and oxidative stress in hyperoxic lung injury by regulating NF-kappaB and Nrf2 pathways. Q J Med 2019; 112: 914–924. - PubMed

Substances