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. 2020 Nov 9;59(46):20274.
doi: 10.1002/anie.202005712. Epub 2020 Apr 28.

Tom N. Grossmann

No authors listed

Tom N. Grossmann

No authors listed. Angew Chem Int Ed Engl. .

Abstract

"My favorite quote is 'All models are wrong, but some are useful' … I advise my students to read first and then go to the lab (can save months of work) …" Find out more about Tom Grossmann in his Author Profile.

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References

My 5 top papers:

    1. “DNA-Catalyzed Transfer of a Reporter Group”: T. N. Grossmann, O. Seitz, J. Am. Chem. Soc. 2006, 128, 15596. (My first scientific publication, and I am still proud of the catalytic activities we achieved. This paper also reminds me of the phenomenal time I had during my PhD in the group of Oliver Seitz.)
    1. “Inhibition of Oncogenic Wnt Signaling Through Direct Targeting of β-Catenin”: T. N. Grossmann, J. T. H. Yeh, B. R. Bowman, Q. Chu, R. E. Moellering, G. L. Verdine, Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 17942. (We report the only crystal structure of a Wnt inhibitor in complex with β-catenin so far, enabled by the help of excellent co-workers and a visionary mentor.)
    1. “Constrained Peptides with Target-Adapted Cross-Links as Inhibitors of a Pathogenic Protein-Protein Interaction”: A. Glas, D. Bier, G. Hahne, C. Rademacher, C. Ottmann, T. N. Grossmann, Angew. Chem. Int. Ed. 2014, 53, 2489;
    1. Angew. Chem. 2014, 126, 2522. (The first research paper from my group still influencing our current work. I am grateful to Christian Ottmann for acquainting us to protein X-ray crystallography).
    1. “Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes”: M. Pelay-Gimeno, A. Glas, O. Koch, T. N. Grossmann, Angew. Chem. Int. Ed. 2015, 54, 8896;

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