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. 2020 Aug;42(4):439-449.
doi: 10.1111/ijlh.13218. Epub 2020 Apr 28.

Hematological performance of a last generation automated blood cell counter: The Mindray BC-6800 Plus

Gina Zini  1   2 , Federica Cantelli  1 , Fernando Scavone  1 , Ombretta Barbagallo  1 , Angela Ciminello  1
Affiliations

Hematological performance of a last generation automated blood cell counter: The Mindray BC-6800 Plus

Gina Zini et al. Int J Lab Hematol. 2020 Aug.

Abstract

Introduction: Hematology analyzers produce reliable, reproducible, precise, accurate results, as well as a premicroscopic characterization of abnormal samples. We have evaluated the clinical performance of a new blood cell counter, which has been temporarily made available to our hematology laboratory.

Methods: Over four months, we analyzed with the Mindray BC-6800 Plus more than 1000 samples with a high incidence of hematological abnormalities, using recommended ICSH and CLSI protocols. We have also assessed flagging efficiency for abnormal cells and scattergram cell distribution.

Results: From a quantitative point of view, our assessment has identified state-of-the-art level reproducibility, excellent linearity, stability over 48°C at 4°C for the conventional parameters, lack of carry-over (<0.2%), and comparability with the routine instruments. These features would make the instrument suitable for immediate and smooth introduction in the hematology laboratory. Flags for abnormal cells are efficient; flag for blast cells has high sensitivity and predictive value of negative results. Additional benefits are provided by a competent interpretation of cell distribution scattergrams in samples from patients with specific hematological disorders.

Conclusion: We have demonstrated good analytical and useful diagnostic performance of this new instrument, including effective selection of abnormal samples for informed microscope morphological analysis.

Keywords: BC 6800 Plus; Mindray; blood cell counter; complete blood count; hematologic neoplasms; performance evaluation.

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References

REFERENCES

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    1. BC-6800 Plus Auto Hematology Analyzer. Operator’s manual. Mindray Bio-medical Electronics Co., Ltd., Shenzhen, China; 2018.
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