Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Aug;125(2):215-217.
doi: 10.1016/j.anai.2020.04.014. Epub 2020 Apr 25.

Detection of allergen component-specific immunoglobulin E with the luciferase immunoprecipitation systems immunoassay

Affiliations

Detection of allergen component-specific immunoglobulin E with the luciferase immunoprecipitation systems immunoassay

Adora A Lin et al. Ann Allergy Asthma Immunol. 2020 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Disclosures: The authors have no conflicts of interest to report.

Figures

Figure 1.
Figure 1.
The LIPS assay detects Fel d 1–specific IgE. Top: Fel d 1 LIPS signal-to-noise ratio in individuals with a negative (n = 74) and positive test result (n = 40) for cat IgE. Bottom: Fel d 1 LIPS signal-to-noise ratio in individuals with a negative (n = 40) and positive (n = 20) test result for Fel d 1 IgE. Significant differences were found among all groups (Kruskal-Wallis test) and between all pairs (Mann-Whitney test). *P < .01. IgE, immunoglobulin E; LIPS, luciferase immunoprecipitation systems.

References

    1. Hamilton RG. Clinical laboratory assessment of immediate-type hypersensitivity. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S284–S296. - PubMed
    1. Cromwell O, Hafner D, Nandy A. Recombinant allergens for specific immunotherapy. J Allergy Clin Immunol. 2011; 127(4):865–872. - PubMed
    1. Burbelo PD, Ching KH, Klimavicz CM, Iadarola MJ. Antibody profiling by Luciferase Immunoprecipitation Systems (LIPS). J Vis Exp. 2009;32:1549. - PMC - PubMed
    1. Nevis IF, Binkley K, Kabali C. Diagnostic accuracy of skin-prick testing for allergic rhinitis: a systematic review and meta-analysis. Allergy Asthma Clin Immunol. 2016;12:20. - PMC - PubMed
    1. Grönlund H, Saarne T, Gafvelin G, van Hage M. The major cat allergen, Fel d 1, in diagnosis and therapy. Int Arch Allergy Immunol. 2010;151(4):265–274. - PubMed

Publication types