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Comment
. 2020 Jul-Aug;8(7):2452-2453.
doi: 10.1016/j.jaip.2020.04.037. Epub 2020 Apr 25.

Debate on drugs that may aggravate COVID-19

Pedro Giavina-Bianchi  1 , Marcelo Vivolo Aun  2 , Rosana Câmara Agondi  2 , Jorge Kalil  2
Affiliations
Comment

Debate on drugs that may aggravate COVID-19

Pedro Giavina-Bianchi et al. J Allergy Clin Immunol Pract. 2020 Jul-Aug.
No abstract available

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Figures

Figure 1
Figure 1
Interaction between the renin-angiotensin-aldosterone system and the bradykinin system. During SARS-CoV-2 infection, there is downregulation of ACE2 at type II pneumocytes surface, decreasing bradykinin degradation. ACE also degrades bradykinin, and drugs that inhibit this enzyme increase bradykinin levels. Red dashed line (ACE, ACE2, and DPP4 degrade bradykinin); blue dashed line (ACE2 degrades angiotensin I to angiotensin 1-9 and angiotensin II to angiotensin 1-7); blue solid line (conversion of angiotensin I to angiotensin II). DPP4, Dipeptidyl peptidase 4.
See this image and copyright information in PMC

Comment on

  • COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic.
    Shaker MS, Oppenheimer J, Grayson M, Stukus D, Hartog N, Hsieh EWY, Rider N, Dutmer CM, Vander Leek TK, Kim H, Chan ES, Mack D, Ellis AK, Lang D, Lieberman J, Fleischer D, Golden DBK, Wallace D, Portnoy J, Mosnaim G, Greenhawt M. Shaker MS, et al. J Allergy Clin Immunol Pract. 2020 May;8(5):1477-1488.e5. doi: 10.1016/j.jaip.2020.03.012. Epub 2020 Mar 26. J Allergy Clin Immunol Pract. 2020. PMID: 32224232 Free PMC article. Review.

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