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. 2020 Jul:140:109770.
doi: 10.1016/j.mehy.2020.109770. Epub 2020 Apr 22.

2019-nCoV-SARS-CoV-2 (COVID-19) infection: Crucıalıty of Furın and relevance wıth cancer

Affiliations

2019-nCoV-SARS-CoV-2 (COVID-19) infection: Crucıalıty of Furın and relevance wıth cancer

Cigdem Usul Afsar. Med Hypotheses. 2020 Jul.
No abstract available

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

    1. COVID-19, a pandemic or not? Lancet Infect Dis 2020 Mar 13. pii: S1473-3099(20)30180-8. doi: 10.1016/S1473-3099(20)30180-8. [Epub ahead of print]. - PubMed
    1. Coutard B., Valle C., de Lamballerie X., Canard B., Seidah N.G., Decroly E. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 2020;176 - PMC - PubMed
    1. Jaaks P., Bernasconi M. The proprotein convertase furin in tumour progression. Int J Cancer. 2017;141(4):654–663. - PubMed
    1. He Z, Thorrez L, Siegfried G, Meulemans S, Evrard S, Tejpar S, et al. The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer. Oncogene 2020 Mar 6. doi: 10.1038/s41388-020-1238-z. [Epub ahead of print]. - PubMed
    1. Braun E., Sauter D. Furin-mediated protein processing in infectious diseases and cancer. Clin Transl Immunol. 2019;8(8) - PMC - PubMed