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Case Reports
. 1988 Nov;148(2):164-6.
doi: 10.1007/BF00445929.

Nephrotoxicity associated with ifosfamide

J Smeitink  1 , M Verreussel, C Schröder, R Lippens
Affiliations
Case Reports

Nephrotoxicity associated with ifosfamide

J Smeitink et al. Eur J Pediatr. 1988 Nov.

Abstract

Three patients developed a Fanconi syndrome with impairment of glomerular function (endogenous creatinine clearance 30-60 ml/min per 1.73 m2) during and/or after treatment with ifosfamide according to the SIOP-MMT 84 protocol in which ifosfamide was given in a dose of 3000 mg/m2 every 4 weeks over a 10-month period. The need for early substitution therapy in patients with the Fanconi syndrome is stressed. The renal lesions in our patients were irreversible.

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References

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