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. 1988 Oct 18;155(3):297-9.
doi: 10.1016/0014-2999(88)90517-1.

Pertussis toxin inactivates the presynaptic serotonin autoreceptor in the hippocampus

F Passarelli  1 , T Costa, O F Almeida
Affiliations

Pertussis toxin inactivates the presynaptic serotonin autoreceptor in the hippocampus

F Passarelli et al. Eur J Pharmacol. .

Abstract

The serotonin (5-HT) agonists, D-lysergic acid diethylamide (LSD) and 5-methoxytryptamine (5-Me-O-T), dose dependently inhibited the K+-evoked outflow of [3H]5-HT from preloaded rat hippocampal slices in vitro, indicating activation of the 5-HT autoreceptor. However, this effect was abolished in slices pretreated with pertussis toxin. It is thus concluded that the 5-HT autoreceptor in the hippocampus is coupled to G proteins.

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