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. 1988 Oct 18;155(3):317-21.
doi: 10.1016/0014-2999(88)90522-5.

Nitric oxide release from the isolated guinea pig heart

M Kelm  1 , J Schrader
Affiliations

Nitric oxide release from the isolated guinea pig heart

M Kelm et al. Eur J Pharmacol. .

Abstract

Nitric oxide (NO) release from isolated guinea pig hearts into the coronary effluent perfusate was measured with a specific spectrophotometric assay. Nitric oxide was continuously released under basal conditions at a rate of 216 +/- 36 pmol/min. Bradykinin (5 X 10(-10)-10(-8) M) stimulated the release of nitric oxide in a dose-dependent manner. The start of NO release preceded coronary vasodilation by 5 +/- 1 s. Our results suggest that the endogenous formation of nitric oxide is quantitatively sufficient to influence the coronary vascular tone and thus may play a significant role in the regulation of coronary vascular resistance.

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