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Comment
. 2020 Aug;45(8):637-638.
doi: 10.1016/j.tibs.2020.04.003. Epub 2020 Apr 25.

Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues

Alisdair R Fernie  1 , Youjun Zhang  2 , Arun Sampathkumar  3
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Comment

Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues

Alisdair R Fernie et al. Trends Biochem Sci. 2020 Aug.
Free article

Abstract

Energy-demanding processes, such as cell growth, migration, and differentiation, are tension modulated, begging the question whether metabolism and mechanical tension are tightly linked. A recent report by Park et al. shows that stiffness in the extracellular matrix (ECM) promotes reorganization of actin, resulting in enhanced glycolysis.

Keywords: E3 ubiquitin ligase tripartite motif (TRIM)-containing protein 21 (TRIM21); F-actin bundling; PFK degradation; cancer; glycolytic regulation.

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  • Mechanical regulation of glycolysis via cytoskeleton architecture.
    Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G. Park JS, et al. Nature. 2020 Feb;578(7796):621-626. doi: 10.1038/s41586-020-1998-1. Epub 2020 Feb 12. Nature. 2020. PMID: 32051585 Free PMC article.

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