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. 2020 Jun;30(6):541-543.
doi: 10.1038/s41422-020-0318-5. Epub 2020 Apr 28.

Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient

Xiao-Hong Yao #  1   2 , Zhi-Cheng He #  1   2 , Ting-Yuan Li #  3 , Hua-Rong Zhang #  1   2 , Yan Wang #  1   2 , Huaming Mou  4 , Qiaonan Guo  5 , Shi-Cang Yu  1   2   6 , Yanqing Ding  7 , Xindong Liu  8   9 , Yi-Fang Ping  10   11 , Xiu-Wu Bian  12   13
Affiliations

Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient

Xiao-Hong Yao et al. Cell Res. 2020 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Pathological observation of the lung tissues.
a Electron microscopic examination on a single pulmonary bronchiolar epithelial cell. Black arrows in left panel indicate organelle in pulmonary epithelial cell. Red arrows in right panel label virus particles. Scale bar: 1 μm in left panel and 200 nm in right panel. b Electron microscopic examination on a single type II alveolar epithelial cell. Yellow arrow indicates organelle in pulmonary epithelial cell. Red arrows label virus particles. Scale bar: 200 nm. c Immunohistochemical (IHC) staining of SARS-CoV-2 nucleoprotein (N) in pulmonary tissue with monoclonal anti-nucleoprotein antibody. The inset represents magnification of the selected area. Dark brown signals indicate positive staining for SARS-CoV-2 nucleoprotein and nuclei are counterstained with hematoxylin. Scale bar: 50 μm. d H&E staining shows desquamated and enlarged epithelial cells. Scale bar: 50 μm. e H&E staining shows exudative monocytes/macrophages in alveoli. Red arrows show typical macrophages in alveoli. Scale bar: 50 μm. f H&E staining shows formation of hyaline membranes. Scale bar: 50 μm. g IHC staining indicates lung-infiltrated immune cells: CD68+ macrophages, CD20+ B cells, and CD8+ T cells. Scale bar: 50 μm.
See this image and copyright information in PMC

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