Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun;17(6):650-652.
doi: 10.1038/s41423-020-0447-2. Epub 2020 Apr 28.

High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients

Wenjing Wang #  1   2 , Bin Su #  3 , Lijun Pang #  1   2 , Luxin Qiao  1   2 , Yingmei Feng  1   2 , Yabo Ouyang  1   2 , Xianghua Guo  1   2 , Hongbo Shi  1   2 , Feili Wei  1   2 , Xiaogang Su  1   2 , Jiming Yin  1   2 , Ronghua Jin  4   5 , Dexi Chen  6   7
Affiliations

High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients

Wenjing Wang et al. Cell Mol Immunol. 2020 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
CyTOF-based analysis identified immune cell signatures in peripheral blood of COVID-19 patients. a Representative viSNE plot of immune cell populations from HDs and COVID-19 patients. b Heatmap of the expression pattern of indicated sorting markers by 31 clusters. c Heatmap of the frequency of displayed clusters among HDs and patients. Compared to HDs, clusters 6–14, 17, and 24–28 declined but clusters 15–16, 18–19, and 29–30 increased among patients with all clinical cases. d Representative image of immune cell populations identified by CyTOF. e The percentage of B cells, DCs, macrophage, monocytes, NK cells, MDSCs, CD8+ T cells, CD4+ T cells, DPT cells, Tregs, and different CD4+/CD8+ T-cell subsets are shown in the heatmap. f Heatmap of indicated cytokine expression in CD4+CD25+CD127- Tregs (upper panel), and CD4+CD8+CD25− DPT cells (lower panel). g Heatmap of TGF-β expression in the indicated immune cells in peripheral blood from HDs and patients under mild, severe, and critical conditions. The color key in the heatmap represents the magnitude of expression (b), cluster abundance (c), signal intensity (d, g), percentage of CD45+ cells(e), and arcsinh ratio by normalizing to the control (f)
See this image and copyright information in PMC

References

    1. Xiao, Y. & Torok, M. E. Taking the right measures to control COVID-19. Lancet Infect. Dis.10.1016/S1473-3099 (2020). - PMC - PubMed
    1. Organization, W. H. Coronavirus disease 2019 (COVID-19). Situation Report-55. https://www.who.int/docs/default-source/coronaviruse/situation-reports/2... (2020).
    1. The Novel Coronavirus Outbreak: What We Know and What We Don’t. Cell180, 1034–1036(2020). - PMC - PubMed
    1. Zhang, C., Shi, L. & Wang, F. S. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol. Hepatol.5, 428–430 (2020). - PMC - PubMed
    1. Yang, X., et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir. Med.10.1016/S2213-2600 (2020). - PMC - PubMed

Publication types