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Comment
. 2020 Aug;17(8):791-793.
doi: 10.1038/s41423-020-0442-7. Epub 2020 Apr 28.

Add on the next level-the time point of the type I IFN response orchestrates the immune response

Angela Wedekind #  1 , David Fritzsch #  1 , Andrea Kröger  2   3
Affiliations
Comment

Add on the next level-the time point of the type I IFN response orchestrates the immune response

Angela Wedekind et al. Cell Mol Immunol. 2020 Aug.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Different expression of type I IFN and IL-6 leads to different antiviral T-cell responses.
In lymph nodes, the early expression of type I IFN during a viral infection leads to a significant production of IL-6 and further to an effective TFH response. The delayed availability of type I IFN does not result in significant IL-6 production and is connected to a Th1 response. If no type I IFN is available during a viral infection, no IL-6 is produced, but a Th1 response is still established.
Fig. 2
Fig. 2. Different polarization of T cells based on spatiotemporal regulation of type I IFN.
In the lymph node, the early availability of type I IFN after a VSV infection leads mainly in type 2 conventional dendritic cells (cDC2s) and monocyte-derived dendritic cells (moDCs) to an increased production of IL-6. This effect drives naive T cells in the paracortical area to differentiate into TFH cells. They migrate into the follicular area and facilitate a strong humoral response by promoting the production of effective neutralizing antibodies. The delayed availability of type I IFN associated with LCMV infection does not influence DCs toward considerable IL-6 production. As a result, a large number of naive T cells differentiate into Th1 cells and, in contrast to TFH cells, promote antiviral activity facilitated by a cellular response.
See this image and copyright information in PMC

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