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. 2020 Jun;47(6):4905-4909.
doi: 10.1007/s11033-020-05449-9. Epub 2020 Apr 28.

Genetic characterization of bovine herpesvirus 4 (BoHV-4) isolates from Argentine cattle suggests a complex evolutionary scenario

Sandra Pérez  1   2 , Julieta Manrique  2   3 , Pedro Morán  4 , Florencia Romeo  5   6 , Hernán Angelini  7 , María Rosa Leunda  8 , Susana Pereyra  8 , Maximiliano Spetter  2 , Erika González Altamiranda  2   8 , Anselmo Odeón  8 , Leandro Jones  2   3 , Andrea Verna  9   10
Affiliations

Genetic characterization of bovine herpesvirus 4 (BoHV-4) isolates from Argentine cattle suggests a complex evolutionary scenario

Sandra Pérez et al. Mol Biol Rep. 2020 Jun.

Abstract

Bovine herpevsirus 4 (BoHV-4) is a gammaherpesvirus that has been associated with different clinical conditions in cattle. In Argentina, BoHV-4 was detected in diverse bovine samples. The aim of this study was to analyze the genetic relationship of 48 field BoHV-4 strains isolated from cattle in Argentina. According to thymidine kinase (tk) gene sequences, BoHV-4 isolates belong to genotypes 1, 2 and 3. Phylogenetic analyses confirmed the presence of the three previously described viral genotypes. However, some of the studied isolates presented conflicting phylogenetic signals between the studied markers. This suggests a complex evolutionary background, that is a history of recombination, incomplete lineage sorting (deep coalescence) or a combination of these, which requires further study. These potential events make difficult the diagnosis of BoHV-4 from clinical samples of cattle and may pose a significant problem for the control of the virus in the herds.

Keywords: Argentinean strains; BoHV-4; Phylogenetic analyses.

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