Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jun;34(6):1189-1190.
doi: 10.1002/ptr.6711. Epub 2020 Apr 29.

Should we try the antiinflammatory natural product, celastrol, for COVID-19?

Solomon Habtemariam  1 , Seyed Fazel Nabavi  2 , Ioana Berindan-Neagoe  3   4   5 , Cosmin Andrei Cismaru  3   6 , Morteza Izadi  2 , Antoni Sureda  7 , Seyed Mohammad Nabavi  2
Affiliations
Comment

Should we try the antiinflammatory natural product, celastrol, for COVID-19?

Solomon Habtemariam et al. Phytother Res. 2020 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest.

Comment on

References

    1. Bugge, T. H. , Antalis, T. M. , & Wu, Q. (2009). Type II transmembrane serine proteases. Journal of Biological Chemistry, 284(35), 23177–23181. - PMC - PubMed
    1. Fan, H. H. , Wang, L. Q. , Liu, W. L. , An, X. P. , Liu, Z. D. , He, X. Q. , … Tong, Y. G. (2020). Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019‐novel coronavirus (2019‐nCoV) related coronavirus model. Chinese Medical Journal, 1. 10.1097/CM9.0000000000000797 - DOI - PMC - PubMed
    1. Han, L. P. , Sun, B. , Li, C. J. , Xie, Y. , & Chen, L. M. (2018). Effect of celastrol on toll‐like receptor 4‐mediated inflammatory response in free fatty acid‐induced HepG2 cells. International Journal of Molecular Medicine, 42(4), 2053–2061. - PMC - PubMed
    1. Heinrich, M. , Appendino, G. , Efferth, T. , Fürst, R. , Izzo, A. A. , Kayser, O. , … Viljoen, A. (2020). Best practice in research–overcoming common challenges in phytopharmacological research. Journal of Ethnopharmacology, 246, 112230. 10.1016/j.jep.2019.112230 - DOI - PubMed
    1. Hoffmann, M. , Kleine‐Weber, H. , Schroeder, S. , Krüger, N. , Herrler, T. , Erichsen, S. , … Nitsche, A. (2020). SARS‐CoV‐2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, 181, 271–280.e8. 10.1016/j.cell.2020.02.052 - DOI - PMC - PubMed