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. 2020 Jul;8(7):e1231.
doi: 10.1002/mgg3.1231. Epub 2020 Apr 29.

Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province

Yujing Cheng  1 , Run Dai  1 , Wanlu Chen  1 , Qi Li  1 , Chan Zhang  1 , Tonghua Yang  2
Affiliations

Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province

Yujing Cheng et al. Mol Genet Genomic Med. 2020 Jul.

Abstract

Background: Pharmacogenomics plays a crucial role in individualized therapy, but the variant information of pharmacogenomics in the Dai population is limited. We therefore aimed to screen very important pharmacogenetic (VIP) in the Dai population and compared differences between Dai and other 25 populations.

Methods: In this study, we genotyped 73 VIP variants from the PharmGKB and compared genotype distribution of variants in Dai with other 25 populations by χ2 test. To assess the genetic relationship among 26 populations, we performed the structure analysis. In addition, pair-wise F-statistics (Fst) was calculated to measure the population differentiation.

Results: We found 12, 10, 13, 17, 11, 39, 46, 46, 45, 43, 49, 46, 46, 46, 49, 45, 41, 42, 48, 53, 45, 50, 50, 51, 47, and 50 significantly different variants in Dai compared with other 25 populations. Genetic structure analysis showed Dai had close relationships with CDX (Chinese Dai in Xishuangbanna), CHB (Han Chinese in Beijing), JPT (Japanese in Tokyo), and KHV (Kinh in Ho Chi Minh City, Vietnam). Moreover, Dai is the most similar to KHV according to Fst analysis.

Conclusions: Our study complement the pharmacogenomics information of Dai population from Yunnan province and provide a theoretical basis for personalized medicine.

Keywords: Dai; genetic polymorphisms; populations; very important pharmacogenetic.

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Conflict of interest statement

We declare no conflict of interest in this study.

Figures

Figure 1
Figure 1
The allele frequencies of PTGS2 rs20417, TPMT rs1142345, and CYP2A6 rs28399433 in 26 populations. 1: Dai, 2: CDX, 3: CHB, 4: JPT, 5: KHV, 6: BEB, 7: GIH, 8: ITU, 9: PJL, 10: STU, 11: CEU, 12: FIN, 13: GBR, 14: IBS, 15: TSI, 16: CLM, 17: MXL, 18: PEL, 19: PUR, 20: ACB, 21: ASW, 22: ESN, 23: GWD, 24: LWK, 25: MSL, 26: YRI
Figure 2
Figure 2
Structure analysis of the genetic relationship of Dai and the other 25 populations
See this image and copyright information in PMC

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