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Comment
. 2020 Jul 1;6(4):258-259.
doi: 10.1093/ehjcvp/pvaa042.

Statin therapy in COVID-19 infection

Vincenzo Castiglione  1 , Martina Chiriacò  1   2 , Michele Emdin  1   3 , Stefano Taddei  2 , Giuseppe Vergaro  1   3
Affiliations
Comment

Statin therapy in COVID-19 infection

Vincenzo Castiglione et al. Eur Heart J Cardiovasc Pharmacother. .
No abstract available

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Figures

Figure 1
Figure 1
Molecular mechanism of actions and proposed advantages of statins in COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), enters the cell through angiotensin-converting enzyme 2 (ACE2). Once in the cell, SARS-CoV-2 causes ACE2 down-regulation, thus reducing its protective effects on various tissues. Coronaviruses are known to induce a proinflammatory host response via the activation of the Toll-like receptor (TLR)–MYD88–NF-κB pathway. Statins are available worldwide, and are low-cost, safe drugs with lipid-lowering and immunomodulatory effects. In experimental models, statins inhibit the MYD88–NF-κB proinflammatory pathway and promote ACE2 up-regulation. Through these mechanisms, statins may prove beneficial in COVID-19 patients. Statins may also counteract hyperlipidaemia caused by some antiviral and immunosuppressive treatments currently used for COVID-19.
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References

    1. Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O.. Potential effects of coronaviruses on the cardiovascular system: a review. JAMA Cardiol 2020;doi: 10.1001/jamacardio.2020.1286. - PubMed
    1. Zeiser R. Immune modulatory effects of statins. Immunology 2018;154:69–75. - PMC - PubMed
    1. Fedson D, Fedson DS.. Treating influenza with statins and other immunomodulatory agents. Antivir Res 2013;99:417–435. - PubMed
    1. Pertzov B, Eliakim-Raz N, Atamna H, Trestioreanu AZ, Yahav D, Leibovici L.. Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults—a systematic review and meta-analysis. Clin Microbiol Infect 2019;25:280–289. - PubMed
    1. Fedson DS, Opal SM, Rordam OM.. Hiding in plain sight: an approach to treating patients with severe COVID-19 infection. mBio 2020;11:doi: 10.1128/mBio.00398-20. - PMC - PubMed

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