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. 2020 Jun 16;222(1):34-37.
doi: 10.1093/infdis/jiaa224.

Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019

Yonghong Zhang  1   2 , Ling Qin  1 , Yan Zhao  1 , Ping Zhang  2   3 , Bin Xu  1 , Kang Li  1 , Lianchun Liang  1 , Chi Zhang  1 , Yanchao Dai  1 , Yingmei Feng  1 , Jianping Sun  1 , Zhongjie Hu  1 , Haiping Xiang  1 , Julian C Knight  2   3 , Tao Dong  2   4 , Ronghua Jin  1
Affiliations

Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019

Yonghong Zhang et al. J Infect Dis. .

Abstract

A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals.

Keywords: COVID-19; IFITM3; rs12252; severe pneumonia.

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References

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