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. 2020 Apr 27;9(5):1264.
doi: 10.3390/jcm9051264.

Salivary Levels of Titanium, Nickel, Vanadium, and Arsenic in Patients Treated with Dental Implants: A Case-Control Study

Piero Papi  1 , Andrea Raco  1 , Nicola Pranno  1 , Bianca Di Murro  1 , Pier Carmine Passarelli  2 , Antonio D'Addona  2 , Giorgio Pompa  1 , Maurizio Barbieri  3
Affiliations

Salivary Levels of Titanium, Nickel, Vanadium, and Arsenic in Patients Treated with Dental Implants: A Case-Control Study

Piero Papi et al. J Clin Med. .

Abstract

Background: Recent articles have hypothesized a possible correlation between dental implants dissolution products and peri-implantitis. The null hypothesis tested in this case-control study was that there would be no differences in salivary concentrations of titanium (Ti), vanadium (V), nickel (Ni) and arsenic (As) ions among patients with dental implants, healthy (Group A) or affected by peri-implantitis (Group B), compared to subjects without implants and/or metallic prosthetic restorations (Group C).

Methods: Inductively coupled plasma mass spectrometry was used to analyze saliva samples. One-way repeated-measure analysis of variance (ANOVA) was used to identify statistically significant differences in the salivary level of Ti, V, Ni and As between the three groups.

Results: A total of 100 patients were enrolled in the study (42 males and 58 females), distributed in three groups: 50 patients in Group C, 26 patients in Group B and 24 patients Group B. In our study, concentrations of metallic ions were higher in Group A and B, compared to the control group, with the exception of vanadium. However, there were no statistically significant differences (p > 0.05) for metallic ions concentrations between Group A and Group B.

Conclusions: Based on our results, there are no differences in titanium or other metals concentrations in saliva of patients with healthy or diseased implants.

Keywords: corrosion; dental implants; metallic ions; saliva; titanium.

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Conflict of interest statement

The authors declare they have no conflicts of interest related to this study.

References

    1. De Angelis F., Papi P., Mencio F., Rosella D., Di Carlo S., Pompa G. Implant survival and success rates in patients with risk factors: Results from a long-term retrospective study with a 10 to 18 years follow-up. Eur. Rev. Med. Pharmacol. Sci. 2017;21:433–437. - PubMed
    1. Rossi F., Lang N.P., Ricci E., Ferraioli L., Baldi N., Botticelli D. Long-term follow-up of single crowns supported by short, moderately rough implants—A prospective 10-year cohort study. Clin. Oral Implant. Res. 2018;29:1212–1219. doi: 10.1111/clr.13386. - DOI - PubMed
    1. Li J., He X., Zhang G., Hang R., Huang X., Tang B., Zhang X. Electrochemical corrosion, wear and cell behavior of ZrO(2)/TiO(2) alloyed layer on Ti-6Al-4V. Bioelectrochemistry. 2018;121:105–114. doi: 10.1016/j.bioelechem.2018.01.011. - DOI - PubMed
    1. Zhang R., Wan Y., Ai X., Liu Z., Zhang D. Corrosion resistance and biological activity of TiO(2) implant coatings produced in oxygen-rich environments. Proc. Inst. Mech. Eng. Part H. 2017;231:20–27. doi: 10.1177/0954411916676507. - DOI - PubMed
    1. Delgado-Ruiz R., Romanos G. Potential Causes of Titanium Particle and Ion Release in Implant Dentistry: A Systematic Review. Int. J. Mol. Sci. 2018;19:3585. doi: 10.3390/ijms19113585. - DOI - PMC - PubMed