Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jun 4;55(6):2001261.
doi: 10.1183/13993003.01261-2020. Print 2020 Jun.

COVID-19 and nicotine as a mediator of ACE-2

Affiliations
Comment

COVID-19 and nicotine as a mediator of ACE-2

Janice M Leung et al. Eur Respir J. .

Abstract

α7-nAChR may upregulate ACE-2 https://bit.ly/2xS0cfT

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: J.M. Leung has nothing to disclose. Conflict of interest: C.X. Yang has nothing to disclose. Conflict of interest: D.D. Sin reports grants from Merck, personal fees for advisory board work from Sanofi-Aventis and Regeneron, grants and personal fees for lectures from Boehringer Ingelheim and AstraZeneca, personal fees for lectures and advisory board worm from Novartis, outside the submitted work.

Figures

FIGURE 1
FIGURE 1
Transcriptome profiles generated through RNA-Seq of airway epithelial cells demonstrated a significant positive correlation between ACE2 and CHRNA7 expression.

Comment in

Comment on

References

    1. Leung JM, Yang CX, Tam A, et al. . ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19. Eur Respir J 2020; 55: 2000688. doi:10.1183/13993003.00688-2020 - DOI - PMC - PubMed
    1. Garg S, Kim L, Whitaker M, et al. . Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019—COVID-NET, 14 States, March 1–30, 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 458–464. doi:10.15585/mmwr.mm6915e3 - DOI - PMC - PubMed
    1. Freedman R, Leonard S, Gault JM, et al. . Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7). Am J Med Genet 2001; 105: 20–22. doi:10.1002/1096-8628(20010108)105:1<20::AID-AJMG1047>3.0.CO;2-C - DOI - PubMed
    1. Guan ZZ, Zhang X, Ravid R, et al. . Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease. J Neurochem 2000; 74: 237–243. doi:10.1046/j.1471-4159.2000.0740237.x - DOI - PubMed
    1. Banerjee C, Nyengaard JR, Wevers A, et al. . Cellular expression of alpha7 nicotinic acetylcholine receptor protein in the temporal cortex in Alzheimer's and Parkinson's disease—a stereological approach. Neurobiol Dis 2000; 7: 666–672. doi:10.1006/nbdi.2000.0317 - DOI - PubMed