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. 2020 Jun;26(6):845-848.
doi: 10.1038/s41591-020-0897-1. Epub 2020 Apr 29.

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-Xin Long #  1 , Bai-Zhong Liu #  2 , Hai-Jun Deng #  1 , Gui-Cheng Wu #  3   4 , Kun Deng #  5 , Yao-Kai Chen #  6 , Pu Liao  7 , Jing-Fu Qiu  8 , Yong Lin  1 , Xue-Fei Cai  1 , De-Qiang Wang  1 , Yuan Hu  1 , Ji-Hua Ren  1 , Ni Tang  1 , Yin-Yin Xu  2 , Li-Hua Yu  2 , Zhan Mo  2 , Fang Gong  2 , Xiao-Li Zhang  2 , Wen-Guang Tian  2 , Li Hu  2 , Xian-Xiang Zhang  3   4 , Jiang-Lin Xiang  3   4 , Hong-Xin Du  3   4 , Hua-Wen Liu  3   4 , Chun-Hui Lang  3   4 , Xiao-He Luo  3   4 , Shao-Bo Wu  3   4 , Xiao-Ping Cui  3   4 , Zheng Zhou  3   4 , Man-Man Zhu  5 , Jing Wang  6 , Cheng-Jun Xue  6 , Xiao-Feng Li  6 , Li Wang  6 , Zhi-Jie Li  7 , Kun Wang  7 , Chang-Chun Niu  7 , Qing-Jun Yang  7 , Xiao-Jun Tang  8 , Yong Zhang  8 , Xia-Mao Liu  9 , Jin-Jing Li  9 , De-Chun Zhang  10 , Fan Zhang  10 , Ping Liu  11 , Jun Yuan  1 , Qin Li  12 , Jie-Li Hu  13 , Juan Chen  14 , Ai-Long Huang  15
Affiliations

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-Xin Long et al. Nat Med. 2020 Jun.

Abstract

We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.

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