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Case Reports
. 2020 Apr 15:2020:3875024.
doi: 10.1155/2020/3875024. eCollection 2020.

Stevens-Johnson Syndrome and Herpes Simplex Type 1 Infection during Adalimumab Therapy for Crohn's Disease

Jenny Roselli  1 , Tommaso Innocenti  1 , Erica Nicola Lynch  1 , Laura Parisio  1 , Pasquale Apolito  1 , Tommaso Mello  1 , Giuseppe Macrì  2 , Monica Milla  2 , Maria Rosa Biagini  1 , Mirko Tarocchi  1 , Stefano Milani  1 , Andrea Galli  1
Affiliations
Case Reports

Stevens-Johnson Syndrome and Herpes Simplex Type 1 Infection during Adalimumab Therapy for Crohn's Disease

Jenny Roselli et al. Case Rep Gastrointest Med. .

Abstract

Stevens-Johnson syndrome (SJS) is a severe mucocutaneous adverse drug reaction with a relatively high mortality rate. SJS is described during herpes simplex virus type 1 (HSV1) infection and, rarely, even during adalimumab therapy. We report the case of a patient with Crohn's disease who developed SJS during an HSV1 infection and a contemporaneous anti-TNFα therapy with adalimumab. Remission was achieved with suspension of adalimumab and high doses of intravenous steroids and antivirals. Patients with HSV1 infection and on adalimumab therapy have a combined risk of SJS and should be monitored closely.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Perioral desquamative lesions.
Figure 2
Figure 2
Palmar desquamative lesions.
See this image and copyright information in PMC

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