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. 2020 Jun;9(2):81-86.
doi: 10.1055/s-0039-3400466. Epub 2019 Nov 21.

Human Rhinovirus/Enterovirus in Pediatric Acute Respiratory Distress Syndrome

Michele E Smith  1 , Patrick T Wilson  1
Affiliations

Human Rhinovirus/Enterovirus in Pediatric Acute Respiratory Distress Syndrome

Michele E Smith et al. J Pediatr Intensive Care. 2020 Jun.

Abstract

The role of human rhinovirus/enterovirus (HRV/HEV) in severe lower respiratory tract infections remains unclear. We characterized the respiratory status of children admitted to a large academic pediatric intensive care unit (PICU) who tested positive for only HRV/HEV. One hundred and fifty-five children met inclusion criteria with 62% requiring positive pressure respiratory support of 5 cm of water pressure or more within the first 24 hours of admission. Among them, 34% had SaO 2 to FiO 2 ratios of 264 or less with 22 patients (14%) meeting criteria for pediatric acute respiratory distress syndrome. HRV/HEV is associated with significant respiratory disease in children admitted to the PICU.

Keywords: enterovirus; pediatric acute respiratory distress syndrome; pediatric intensive care units; rhinovirus.

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Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
Enrolment flow chart. CSF, cerebrospinal fluid; PICU, pediatric intensive care unit; RPP, respiratory pathogen panel.
Fig. 2
Fig. 2
Number of admissions for children positive for only HRV/HEV by calendar month. HEV, enterovirus; HRV, rhinovirus.
See this image and copyright information in PMC

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