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Comment
. 2020 Aug;40(8):2038-2040.
doi: 10.1111/liv.14500. Epub 2020 Jun 10.

SARS-CoV-2 virus and liver expression of host receptors: Putative mechanisms of liver involvement in COVID-19

Carlos J Pirola  1   2 , Silvia Sookoian  1   3
Affiliations
Comment

SARS-CoV-2 virus and liver expression of host receptors: Putative mechanisms of liver involvement in COVID-19

Carlos J Pirola et al. Liver Int. 2020 Aug.
No abstract available

Keywords: ACE2; COVID-19; FURIN; SARS-CoV-2; TMPRSS2; host; liver; single-cell transcriptomics.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Liver gene expression profiling across cell types of host receptors implicated in SARS‐CoV‐2 infection. Profiling of gene expression was retrieved from the Single Cell Portal available at https://singlecell.broadinstitute.org/single_cell. The analysis was focused on the adult liver dataset from the Human Cell Atlas March 2020 Release, a collection of 23 human single‐cell datasets. The human liver cellular landscape analysis by single cell RNA‐seq is based on the study of MacParland et al Human liver tissue was obtained from livers procured from deceased donors deemed acceptable for liver transplantation. A, Annotation of liver whole transcriptome involved 15 clusters, including hepatocytes, alpha‐beta T cells, central liver sinusoidal endothelial cells, cholangiocytes, erythroid cells, gamma‐delta T cells, hepatic stellate cells, inflammatory macrophage, mature B cells, natural killer cells, non‐inflammatory macrophages, periportal liver sinusoidal endothelial cells, plasma cells, portal liver sinusoidal endothelial cells and unannotated cells (A). B, To illustrate the pattern and magnitude of differential gene expression levels at different cells in the liver, we assessed the pattern of gene expression of albumin (ALB)—the most abundant protein in human blood that is highly expressed in the liver. C‐E, Exploration of ACE2, TMPRSS and FURIN expression in the liver
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References

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