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. 2020 Apr;23(5):277-287.
doi: 10.14744/AnatolJCardiol.2020.01379.

Assessment of right ventricular function in patients with pulmonary arterial hypertension-congenital heart disease and repaired and unrepaired defects: Correlation among speckle tracking, conventional echocardiography, and clinical parameters

Hatice S Kemal  1 , Meral Kayıkçıoğlu  2 , Sanem Nalbantgil  2 , Levent Hürkan Can  2 , Nesrin Moğulkoç  3 , Hakan Kültürsay  2
Affiliations

Assessment of right ventricular function in patients with pulmonary arterial hypertension-congenital heart disease and repaired and unrepaired defects: Correlation among speckle tracking, conventional echocardiography, and clinical parameters

Hatice S Kemal et al. Anatol J Cardiol. 2020 Apr.

Abstract

Objective: The purpose of this study is to compare the analysis of right ventricular (RV) free wall strain via 2D speckle tracking echocardiography with conventional echocardiography and clinical parameters in patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) receiving specific treatment. This study also aims to describe the differences between patients with repaired and unrepaired defects.

Methods: This prospective study included 44 adult patients with PAH-CHD who were receiving PAH-specific treatment in a single center. This study excluded patients with complex congenital heart disease. The authors studied the conventional echocardiographic parameters, such as RV fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE), right atrial (RA) area, Tricuspid S', and hemodynamic parameters, such as functional class, 6-minute walking distance (6MWD), and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels.

Results: The mean age of participants was 33.8±11.6 years, and 65.9% of participants were female. The mean RV free wall strain was -14.8±4.7%. Majority of the patients belonged to WHO functional class 2 (61.4%) with a mean NT-proBNP level of 619.2±778.4 and mean 6MWD of 400.2±86.9 meters. During the follow-up of 30.8±9.0 months, 6 patients (13.6%) developed clinical right heart failure, whereas 9 (20.5%) of them died. There was a positive and significant correlation between RV free wall strain and WHO functional class (r=0.320, p=0.03), whereas there was a negative correlation between RV free wall strain and FAC (r=-0.392, p=0.01), TAPSE (r=-0.577, p=0.0001), and Tricuspid S' (r=-0.489, p=0.001). There was no significant correlation of RV free wall strain with either RA area or 6MWD. Patients with repaired congenital heart defects had worse RV functional parameters and RV free wall strain than patients with unrepaired defects.

Conclusion: The assessment of RV free wall strain via 2D speckle tracking echocardiography is a feasible method and correlates well with conventional echocardiography and clinical parameters in patients with PAH-CHD receiving specific treatment. (Anatol J Cardiol 2020; 23: 277-87).

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Conflict of interest statement

Conflict of interest: Financial/nonfinancial disclosures; Dr. Kemal has no conflict of interest to declare with respect to this paper. For the last two years, Dr. Kayıkçıoğlu has received honoraria (for lectures and consultancy) from Abdi İbrahim, Actelion, Bayer Schering, Deva, Sanofi, and research funding from Actelion, and has participated in clinical trials with Actelion, Bayer Schering. Dr. Nalbantgil has received honoraria (for clinical trials, lectures, and consultancy) from AMGEN, Medtronic, Abbot, Abdi İbrahim, Actelion, Bayer Schering, and Pfizer. Dr. Can has no conflict of interest to declare with respect to this paper. Dr. Moğulkoç has no conflict of interest to declare with respect to this paper. Dr. Kültürsay has no conflict of interest to declare with respect to this paper.

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