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Meta-Analysis
. 2020 Apr 29;4(4):CD012662.
doi: 10.1002/14651858.CD012662.pub2.

Organisational interventions for preventing and minimising aggression directed towards healthcare workers by patients and patient advocates

Affiliations
Meta-Analysis

Organisational interventions for preventing and minimising aggression directed towards healthcare workers by patients and patient advocates

Evelien Spelten et al. Cochrane Database Syst Rev. .

Abstract

Background: Workplace aggression is becoming increasingly prevalent in health care, with serious consequences for both individuals and organisations. Research and development of organisational interventions to prevent and minimise workplace aggression has also increased. However, it is not known if interventions prevent or reduce occupational violence directed towards healthcare workers.

Objectives: To assess the effectiveness of organisational interventions that aim to prevent and minimise workplace aggression directed towards healthcare workers by patients and patient advocates.

Search methods: We searched the following electronic databases from inception to 25 May 2019: Cochrane Central Register of Controlled Trials (CENTRAL) (Wiley Online Library); MEDLINE (PubMed); CINAHL (EBSCO); Embase (embase.com); PsycINFO (ProQuest); NIOSHTIC (OSH-UPDATE); NIOSHTIC-2 (OSH-UPDATE); HSELINE (OSH-UPDATE); and CISDOC (OSH-UPDATE). We also searched the ClinicalTrials.gov (www.ClinicalTrials.gov) and the World Health Organization (WHO) trials portals (www.who.int/ictrp/en).

Selection criteria: We included randomised controlled trials (RCTs) or controlled before-and-after studies (CBAs) of any organisational intervention to prevent and minimise verbal or physical aggression directed towards healthcare workers and their peers in their workplace by patients or their advocates. The primary outcome measure was episodes of aggression resulting in no harm, psychological, or physical harm.

Data collection and analysis: We used standard Cochrane methods for data collection and analysis. This included independent data extraction and 'Risk of bias' assessment by at least two review authors per included study. We used the Haddon Matrix to categorise interventions aimed at the victim, the vector or the environment of the aggression and whether the intervention was applied before, during or after the event of aggression. We used the random-effects model for the meta-analysis and GRADE to assess the quality of the evidence.

Main results: We included seven studies. Four studies were conducted in nursing home settings, two studies were conducted in psychiatric wards and one study was conducted in an emergency department. Interventions in two studies focused on prevention of aggression by the vector in the pre-event phase, being 398 nursing home residents and 597 psychiatric patients. The humour therapy in one study in a nursing home setting did not have clear evidence of a reduction of overall aggression (mean difference (MD) 0.17, 95% confidence interval (CI) 0.00 to 0.34; very low-quality evidence). A short-term risk assessment in the other study showed a decreased incidence of aggression (risk ratio (RR) 0.36, 95% CI 0.16 to 0.78; very low-quality evidence) compared to practice as usual. Two studies compared interventions to minimise aggression by the vector in the event phase to practice as usual. In both studies the event was aggression during bathing of nursing home patients. In one study, involving 18 residents, music was played during the bathing period and in the other study, involving 69 residents, either a personalised shower or a towel bath was used. The studies provided low-quality evidence that the interventions may result in a medium-sized reduction of overall aggression (standardised mean difference (SMD -0.49, 95% CI -0.93 to -0.05; 2 studies), and physical aggression (SMD -0.85, 95% CI -1.46 to -0.24; 1 study; very low-quality evidence), but not in verbal aggression (SMD -0.31, 95% CI; -0.89 to 0.27; 1 study; very low-quality evidence). One intervention focused on the vector, the pre-event phase and the event phase. The study compared a two-year culture change programme in a nursing home to practice as usual and involved 101 residents. This study provided very low-quality evidence that the intervention may result in a medium-sized reduction of physical aggression (MD 0.51, 95% CI 0.11 to 0.91), but there was no clear evidence that it reduced verbal aggression (MD 0.76, 95% CI -0.02 to 1.54). Two studies evaluated a multicomponent intervention that focused on the vector (psychiatry patients and emergency department patients), the victim (nursing staff), and the environment during the pre-event and the event phase. The studies included 564 psychiatric staff and 209 emergency department staff. Both studies involved a comprehensive package of actions aimed at preventing violence, managing violence and environmental changes. There was no clear evidence that the psychiatry intervention may result in a reduction of overall aggression (odds ratio (OR) 0.85, 95% CI 0.63 to 1.15; low-quality evidence), compared to the control condition. The emergency department study did not result in a reduction of aggression (MD = 0) but provided insufficient data to test this.

Authors' conclusions: We found very low to low-quality evidence that interventions focused on the vector during the pre-event phase, the event phase or both, may result in a reduction of overall aggression, compared to practice as usual, and we found inconsistent low-quality evidence for multi-component interventions. None of the interventions included the post-event stage. To improve the evidence base, we need more RCT studies, that include the workers as participants and that collect information on the impact of violence on the worker in a range of healthcare settings, but especially in emergency care settings. Consensus on standardised outcomes is urgently needed.

PubMed Disclaimer

Conflict of interest statement

Evelien Spelten: none known

Brodie Thomas: none known

Peter O'Meara: I have published a paper with Professor Maguire on paramedic safety. I am currently undertaking a research project titled 'Violence against paramedics' that is funded by the Falck Foundation.

Brian Maguire: I have an interest in violence in the workplace and I have published extensively in this area of interest, with a focus on occupational violence against paramedics. I am currently undertaking a research project with Professor Peter O'Meara titled 'Violence against paramedics' that is funded by the Falck Foundation.

Deirdre FitzGerald: I have published a paper on the incidence of violence in community pharmacies in the Republic of Ireland.

Stephen Begg: none known

Figures

1
1
Study flow diagram.
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
1.1
1.1. Analysis
Comparison 1: Vector‐directed at pre‐event versus practice as usual, Outcome 1: Incident scale (medium term)
1.2
1.2. Analysis
Comparison 1: Vector‐directed at pre‐event versus practice as usual, Outcome 2: Incident count (medium term)
2.1
2.1. Analysis
Comparison 2: Vector‐directed at event versus practice as usual, Outcome 1: Incident scale (short term)
3.1
3.1. Analysis
Comparison 3: Vector‐directed at pre‐event/event versus practice as usual, Outcome 1: Incident scale (long term)
4.1
4.1. Analysis
Comparison 4: Multicomponent versus practice as usual, Outcome 1: Incident count (medium term)
5.1
5.1. Analysis
Comparison 5: Multicomponent versus physical fitness, Outcome 1: Incident count (short term)

Update of

References

References to studies included in this review

Bowers 2015 {published data only}
    1. Bowers L, James K, Quirk A, Simpson A, Stewart D, Hodsoll J, SUGAR. Reducing conflict and containment rates on acute psychiatric wards: The Safewards cluster randomised controlled trial. International Journal of Nursing Studies 2015;52(9):1412-1422. - PMC - PubMed
Burack 2012 {published data only}
    1. Burack OR, Weiner AS, Reinhardt JP. The impact of culture change on elders' behavioral symptoms: a longitudinal study. Journal of the American Medical Directors Association 2012;13(6):522-528. [DOI: ] - PubMed
Clark 1998 {published data only}
    1. Clark, M, Lipe, A, Bilbrey, M. Use of music to decrease aggressive behaviors in people with dementia. Journal of Gerontological Nursing 1998;24(7):10-17. [DOI: https://doi.org/10.3928/0098-9134-19980701-05]] - PubMed
Gillespie 2014 {published data only}
    1. Gillespie, GL, Gates, DM, Kowalenko, T, Bresler, S, Succop, P. Implementation of a comprehensive intervention to reduce physical assaults and threats in the Emergency Department. Journal of Emergency Nursing 2014;40(6):586-591. - PubMed
Low 2014 {published data only}
    1. Low, L, Goodenough, B, Fletcher, J, Xu, K, Casey, A, Chenoweth, L, Fleming, R Spitzer, P, Belld, JP Brodaty, H. The effects of humor therapy on nursing home residents measured using observational methods: the SMILE cluster randomized trial. Journal of the American Medical Directors Association 2014;15(8):564-569. [DOI: ] - PubMed
Sloane 2004 {published data only}
    1. Sloane, PD, Hoeffer, B, Mitchell, CM, McKenzie, DA, Barrick, AL, Rader, J, Stewart, BJ, Talerico, KA, Rasin, JH, Zink RC, Koch GG. Effect of person-centered showering and the towel bath on bathing-associated aggression, agitation, and discomfort in nursing home residents with dementia: a randomized, controlled trial. Journal of the American Geriatrics Society 2004;52(11):1795-1804. [DOI: 10.1111/j.1532-5415.2004.52501.x] - DOI - PubMed
van de Sande 2011 {published data only}
    1. van de Sande, R, Nijman, HL, Noorthoorn, EO, Wierdsma, AI, Hellendoorn, E, van der Staak, C, Mulder, CL. Aggression and seclusion on acute psychiatric wards: effect of short-term risk assessment. The British Journal of Psychiatry: The Journal of Mental Science 2011;199(6):473-478. [DOI: 10.1192/bjp.bp.111.095141] - DOI - PubMed

References to studies excluded from this review

Abderhalden 2004 {published data only}
    1. Abderhalden, C, Needham, I, Miserez, B, Almvik, R, Dassen, T, Haug, H-J, Fischer, J E. Predicting inpatient violence in acute psychiatric wards using the Broset-Violence-Checklist: a multicentre prospective cohort study. Journal of Psychiatric and Mental Health Nursing 2004;11(4):422-427. - PubMed
Abraham 2001 {published data only}
    1. Abraham, A, Cheng, T L, Wright, J L, Addlestone, I, Huang, Z, Greenberg, L. Assessing an educational intervention to improve physician violence screening skills. Pediatrics 2001;107(5):E68. - PubMed
Abushakra 2012 {published data only}
    1. Abushakra, S, Lyketsos, C, Crans, G, Nadkarni, P, Hernandez, C, Vellas B. The effects of ELND005 (scyllo-inositol) on agitation/aggression in ad dementia: Results from a 78 week phase 2 study in mild to moderate AD. Journal of Nutrition, Health and Aging 2012;16(9):802.
Adams 2017 {published data only}
    1. Adams, J. Assessing the effectiveness of clinical education to reduce the frequency and recurrence of workplace violence. Australian Journal of Advanced Nursing 2017;34(3):6-15.
Adamson 2009 {published data only}
    1. Adamson, MA, Vincent, AA, Cundiff, J. Common ground not a battle ground: violence prevention at a detoxification facility.. Journal of Psychosocial Nursing & Mental Health Services 2009;47(8):28-35. [DOI: 10.3928/02793695-20090706-01] - DOI - PubMed
Alexander 2004a {published data only}
    1. Alexander, J, Tharyan, P, Adams, C, John, T, Mol, C, Philip, J. Rapid tranquillization of violent or agitated patients in a psychiatric emergency setting: Pragmatic randomised trial of intramuscular lorazepam v. haloperidol plus promethazine. The British Journal of Psychiatry 2004;185(1):63-69. [DOI: ] - PubMed
Alexander 2004b {published data only}
    1. Alexander, J, Tharyan, P, Adams, C, John, T, Mol, C, Philip, J. Rapid tranquillisation of violent or agitated patients in a psychiatric emergency setting. Pragmatic randomised trial of intramuscular lorazepam v. haloperidol plus promethazine. The British Journal of Psychiatry: The Journal of Mental Science 2004;185(0342367, b1k):63-69. - PubMed
Algwaiz 2012 {published data only}
    1. Algwaiz, WM, Alghanim, SA. Violence exposure among health care professionals in Saudi public hospitals. A preliminary investigation. Saudi Medical Journal 2012;33(1):76-82. - PubMed
Alibeu 1990 {published data only}
    1. Alibeu, JP, Jobert, J. Aconite in homeopathic relief of post-operative pain and agitation in children. Pediatrie 1990;45(7-8):465-6. - PubMed
Allen 2011 {published data only}
    1. Allen, MH, Debanne, M Lazignac, C Adam, E Dickinson, LM, Damsa, C. Effect of nicotine replacement therapy on agitation in smokers with schizophrenia: a double-blind, randomized, placebo-controlled study. The American Journal of Psychiatry 2011;168(4):395-399. - PubMed
Ananth 1972 {published data only}
    1. Ananth, JV, Salib, M, Ban, TA, , Lehmann, HE. Propericiazine in psychiatric emergencies. A controlled comparative study. Canadian Psychiatric Association Journal 1972;17(2):143-145. - PubMed
Anderson 2006 {published data only}
    1. Anderson, C. Training efforts to reduce reports of workplace violence in a community health care facility. Journal of Professional Nursing : Official Journal of the American Association of Colleges of Nursing 2006;22(5):289-295. - PubMed
Andrezina 2006 {published data only}
    1. Andrezina, R, Marcus, RN, Oren, DA, Manos, G, Stock, E, Carson, WH McQuade, RD. Intramuscular aripiprazole or haloperidol and transition to oral therapy in patients with agitation associated with schizophrenia: Sub-analysis of a double-blind study. Current Medical Research and Opinion 2006;22(11):2209-2219. [DOI: ] - PubMed
Anonymous 2007 {published data only}
    1. Atypical antipsychotics minimally effective in Alzheimer's. Journal of Family Practice 2007;56(1):14. - PubMed
Arbach Lucioni 2011 {published data only}
    1. Arbach-Lucioni, K, Andres-Pueyo, A, Pomarol-Clotet, E, Gomar-Sones, J. Predicting violence in psychiatric inpatients: A prospective study with the HCR-20 violence risk assessment scheme. Journal of Forensic Psychiatry and Psychology 2011;22(2):203-222. [DOI: ]
Arnetz 2000 {published data only}
    1. Arnetz, JE, Arnetz, BB. Implementation and evaluation of a practical intervention programme for dealing with violence towards health care workers. Journal of Advanced Nursing 2000;31(3):668-680. - PubMed
Arnetz 2016 {published data only}
    1. Arnetz, J, Luborsky, M, Ager, J, Janisse, J, Upfal, M. Using a system-wide database to reduce workplace violence in hospitals. Wayne State University 2016.
Arnetz 2017 {published data only}
    1. Arnetz, J, Hamblin, L, Russell, J, Upfal, M, Luborsky, M, Janisse, J, Essenmacher, L. Preventing patient-to-worker violence in hospitals: outcome of a randomized controlled intervention. Journal of Occupational and Environmental Medicine 2017;59(1):18-27. [DOI: 10.1097/JOM.0000000000000909] - DOI - PMC - PubMed
Asadollahi 2015 {published data only}
    1. Asadollahi, S, Heidari, K, Hatamabadi, H, Vafaee, R, Yunesian, S, Azadbakht, A, Mirmohseni, L. Efficacy and safety of valproic acid versus haloperidol in patients with acute agitation: Results of a randomized, double-blind, parallel-group trial. International Clinical Psychopharmacology 2015;30(3):142-150. [DOI: 10.1097/YIC.0000000000000064] - DOI - PubMed
Baker 2003 {published data only}
    1. Baker, RW, Kinon, BJ, Maguire, GA, , Liu, H, Hill, AL. Effectiveness of rapid initial dose escalation of up to forty milligrams per day of oral olanzapine in acute agitation.. Journal of Clinical Psychopharmacology 2003;23(4):342-348. - PubMed
Baldacara 2010 {published data only}
    1. Baldacara, L, Cordeiro, DC, Sanches, M, Jackowski, AP. Rapid tranquillisation for agitated patients in emergency psychiatric rooms: A randomised trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol. Biological Psychiatry 2010;67(9 SUPPL. 1):75S. [DOI: ] - PubMed
Barbui 2008 {published data only}
    1. Barbui, C. Intramuscular haloperidol plus promethazine is more effective and safer than haloperidol alone for rapid tranquillisation of agitated mentally ill patients.. Evidence Based Mental Health 2008;11(3):86-87. - PubMed
Battaglia 1997 {published data only}
    1. Battaglia, J, Moss, S, Rush, J, Kang, J, Mendoza, R, Leedom, L, Dubin, W, McGlynn, C, Goodman, L. Haloperidol, lorazepam, or both for psychotic agitation? A multicenter, prospective, double-blind, emergency department study.. The American Journal of Emergency Medicine 1997;15(4):335-340. - PubMed
Beck 1997 {published data only}
    1. Beck, N, Greenfield, S, Gotham, H, Menditto, A, Stuve, P, Hemme, C. Risperidone in the management of violent, treatment-resistant schizophrenics hospitalized in a maximum security forensic facility. Journal of the American Academy of Psychiatry and the Law 1997;25(4):461-468. - PubMed
Beck 2002 {published data only}
    1. Beck, CK, Vogelpohl, TS, Rasin, JH, Uriri, JT, O'Sullivan, P, Walls, R, Phillips, R, Baldwin, B. Effects of behavioral interventions on disruptive behavior and affect in demented nursing home residents.. Nursing Research 2002;51(4):219-228. - PubMed
Bergk 2011 {published data only}
    1. Bergk, J, Einsiedler, B, Flammer, E Steinert, T. A randomized controlled comparison of seclusion and mechanical restraint in inpatient settings. Psychiatric Services (Washington, D.C.) 2011;62(11):1310-1317. [DOI: 10.1176/ps.62.11.pss6211_1310] - DOI - PubMed
Bieniek 1998 {published data only}
    1. Bieniek, SA, Ownby, RL, Penalver, A, Dominguez, RA. A double-blind study of lorazepam versus the combination of haloperidol and lorazepam in managing agitation.. Pharmacotherapy 1998;18(1):57-62. - PubMed
Bowers 2006 {published data only}
    1. Bowers, L, Brennan, G, Flood, C, Lipang, M, Oladapo, P. Preliminary outcomes of a trial to reduce conflict and containment on acute psychiatric wards: City Nurses.. Journal of Psychiatric and Mental Health Nursing 2006;13(2):165-172. - PubMed
Bowers 2008 {published data only}
    1. Bowers, L, Flood, C, Brennan, G, Allan, T. A replication study of the City nurse intervention: reducing conflict and containment on three acute psychiatric wards.. Journal of Psychiatric and Mental Health Nursing 2008;15(9):737-742. - PubMed
Burton 1995 {published data only}
    1. Burton, LC, Rovner, BW, German, PS, Brant, LJ, Clark, RD. Neuroleptic use and behavioral disturbance in nursing homes: a 1-year study.. International Psychogeriatrics 1995;7(4):535-545. - PubMed
Cailhol 2007 {published data only}
    1. Cailhol, L, Allen, M, Moncany, A, Cicotti, A, Virgillito, S, Barbe, RP, Lazignac, C, Damsa, C. Violent behavior of patients admitted in emergency following drug suicidal attempt: a specific staff educational crisis intervention.. General Hospital Psychiatry 2007;29(1):42-44. - PubMed
Calver 2010 {published data only}
    1. Calver, LA, Downes, MA, Page, CB, Bryant, JL, Isbister, GK. The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department.. BMC Emergency Medicine 2010;10(100968543):14. - PMC - PubMed
Calver 2015 {published data only}
    1. Calver, L, Drinkwater, V, Gupta, R, Page, C, Isbister, G. Droperidol v. haloperidol for sedation of aggressive behaviour in acute mental health: randomised controlled trial. The British Journal of Psychiatry: The Journal of Mental Science 2015;206(3):223-228. [DOI: 10.1192/bjp.bp.114.150227] - DOI - PubMed
Carlowe 2011 {published data only}
    1. Carlowe J. Screens to update patients in emergency departments about their progress can help to reduce aggression. BMJ (Clinical research Ed.) 2011;343:d7487. - PubMed
Chan 2006 {published data only}
    1. Chan, K, Campayo, A, Moser, D, Arndt, S, Robinson, R. Aggressive behavior in patients with stroke: association with psychopathology and results of antidepressant treatment on aggression. Archives of Physical Medicine and Rehabilitation 2006;87(6):793-798. [DOI: 10.1016/j.apmr.2006.02.016] - DOI - PubMed
Chou 2016 {published data only}
    1. Chou, W, Waszynski, C, Kessler, J, Chiang, Y, Clarkson, PJ. Using positive images to manage resistance-to-care and combative behaviors in nursing home residents with dementia: A pilot study.. Geriatric Nursing (New York, N.Y.) 2016;37(3):215-220. - PubMed
Chu 2013 {published data only}
    1. Chu, CM, Thomas, SD, Daffern, M, Ogloff, JR, . Should clinicians use average or peak scores on a dynamic risk-assessment measure to most accurately predict inpatient aggression? International Journal of Mental Health Nursing 2013;22(6):493-499. [DOI: 10.1111/j.1447-0349.2012.00846.x] - DOI - PubMed
Citrome 2001 {published data only}
    1. Citrome, L, Volavka, J, Czobor, P, Sheitman, B, Lindenmayer, JP, McEvoy, J, Cooper, TB Chakos, M, Lieberman, JA. Effects of clozapine, olanzapine, risperidone, and haloperidol on hostility among patients with schizophrenia.. Psychiatric Services (Washington, D.C.) 2001;52(11):1510-1514. - PubMed
Citrome 2007 {published data only}
    1. Citrome, L, Shope, CB, Nolan, KA, Czobor, P, Volavka, J. Risperidone alone versus risperidone plus valproate in the treatment of patients with schizophrenia and hostility.. International Clinical Psychopharmacology 2007;22(6):356-362. - PubMed
Crawford 2004 {published data only}
    1. Crawford, MJ, Patton, R, Touquet, R, Drummond, C, Byford, S, Barrett, B, Reece, B, Brown, A, Henry, JA. Screening and referral for brief intervention of alcohol-misusing patients in an emergency department: a pragmatic randomised controlled trial.. Lancet 2004;364 North American Edition(9442):1334-1339. - PubMed
Currier 2001 {published data only}
    1. Currier, GW, Simpson, GM. Risperidone liquid concentrate and oral lorazepam versus intramuscular haloperidol and intramuscular lorazepam for treatment of psychotic agitation. Journal of Clinical Psychiatry 2001;62(3):153-157. - PubMed
Esmailian 2015 {published data only}
    1. Esmailian, M, Ahmadi, O, Taheri, M, Zamani, M. Comparison of haloperidol and midazolam in restless management of patients referred to the Emergency Department: A double-blinded, randomized clinical trial.. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences 2015;20(9):844-849. - PMC - PubMed
FlanneryJr 1998 {published data only}
    1. Flannery, JR, Hanson, MA, Penk, WE, Goldfinger, S, Pastva, G, Navon, MA. Replicated declines in assault rates after implementation of the assaulted staff action program. Psychiatric Services 1998;49(2):241-243. - PubMed
Ford 2007 {published data only}
    1. Ford, K. A hospital-based violence prevention intervention reduced hospital recidivism for violent injury and arrests for violent crimes. Evidence-Based Medicine 2007;12(4):110. [DOI: ] - PubMed
Geoffrion 2017 {published data only}
    1. Geoffrion, S, Goncalves, J, Giguere, C, Guay, S. Impact of a program for the management of aggressive behaviors on seclusion and restraint use in two high-risk units of a mental health institute.. The Psychiatric Quarterly 2017;89(1):95-102. - PubMed
Gerdtz 2006 {published data only}
    1. Gerdtz, M, Cowling, S. System responses to clinical aggression: implications for monitoring and preventing risk in acute care...CENA 2006 National Conference abstracts. Australasian Emergency Nursing Journal 2006;9(3):135-135.
Gormley 2001 {published data only}
    1. Gormley, N, Lyons, D, Howard, R. Behavioural management of aggression in dementia: a randomized controlled trial. Age and Ageing 2001;30(2):141-145. - PubMed
Hick 2001 {published data only}
    1. Hick, JL, Mahoney, BD, Lappe, M. Prehospital sedation with intramuscular droperidol: a one-year pilot.. Prehospital Emergency Care 2001;5(4):391-394. - PubMed
Hill 2015 {published data only}
    1. Hill, AK, Lind, MA, Tucker, D, Nelly, P, Daraiseh, N. Measurable results: Reducing staff injuries on a specialty psychiatric unit for patients with developmental disabilities.. Work (Reading, Mass.) 2015;51(1):99-111. - PubMed
Hoeffer 2006 {published data only}
    1. Hoeffer, B, Talerico, KA, Rasin, J, Mitchell, CM, Stewart, BJ, McKenzie, D, Barrick, AL, Rader, J, Sloane, PD. Assisting cognitively impaired nursing home residents with bathing: effects of two bathing interventions on caregiving.. The Gerontologist 2006;46(4):524-532. - PubMed
Holliday Welsh 2009 {published data only}
    1. Holliday-Welsh, DM, Gessert, CE, Renier, CM. Massage in the management of agitation in nursing home residents with cognitive impairment.. Geriatric Nursing 2009;30(2):108-117. [DOI: 10.1016/j.gerinurse.2008.06.016] - DOI - PubMed
Huf 2002a {published data only}
    1. Huf, G, Coutinho, ES, Adams, CE, TREC-Rio trial. TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].. BMC Psychiatry 2002;2(100968559):11. - PMC - PubMed
Huf 2002b {published data only}
    1. Huf, G, Coutinho, E, Adams, C. TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms. BMC Psychiatry 2002;2(1):11. - PMC - PubMed
Huf 2003 {published data only}
    1. Huf, G. Rapid tranquillisation for agitated patients in emergency psychiatric rooms: A randomised trial of midazolam versus haloperidol plus promethazine. British Medical Journal 2003;327(7417):708-711. - PMC - PubMed
Huf 2007 {published data only}
    1. Huf, G, Coutinho, EE, Adams, CE, TREC Collaborative Group. Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine.. BMJ (Clinical Research Ed.) 2007;335(7625):869. - PMC - PubMed
Huf 2010 {published data only}
    1. Huf, G, Coutinho, ES, Adams, CE. The pharmacological management of agitated patients in emergency psychiatric hospitals in Rio de Janeiro - Brazil: The results of two pragmatic randomized clinical trials. Schizophrenia Research 2010;117(2-3):376. [DOI: ]
Huf 2011 {published data only}
    1. Huf, G, Coutinho, ES, Ferreira, MA, Ferreira, S, Mello, F, Adams, CE, TREC-SAVE Collaborative group. TREC-SAVE: A randomised trial comparing mechanical restraints with use of seclusion for aggressive or violent seriously mentally ill people: Study protocol for a randomised controlled trial.. Trials 2011;12(101263253):180. - PMC - PubMed
Huf 2012 {published data only}
    1. Huf, G, Coutinho, EE, Adams, CE, TREC-SAVE Collaborative Group. Physical restraints versus seclusion room for management of people with acute aggression or agitation due to psychotic illness (TREC-SAVE): A randomized trial.. Psychological medicine 2012;42(11):2265-2273. - PubMed
Hurley 2008 {published data only}
    1. Hurley, AD. Antipsychotics for aggressive behaviour: No better than placebo for non-psychotic adults with learning difficulties. Evidence Based Mental Health 2008;11(3):85-85. - PubMed
Ideker 2011 {published data only}
    1. Ideker, K, Todicheeney-Mannes, D, Kim, SC. A confirmatory study of violence risk assessment tool (M55) and demographic predictors of patient violence. Journal of Advanced Nursing 2011;67(11):2455-2462. - PubMed
Isbister 2010a {published data only}
    1. Isbister, GK, Calver, LA, Page, CB, Stokes, B, Bryant, JL, Downes, MA. Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: The DORM Study. Annals of Emergency Medicine 2010;56(4):392-401.e1. [DOI: 10.1016/j.annemergmed.2010.05.037] - DOI - PubMed
Isbister 2010b {published data only}
    1. Isbister, GK, Calver, LA, Page, CB, Stoke, B, Bryant, JL, Downes, MA. Randomised comparison study of intramuscular droperidol versus midazolam for violence and acute behavioural disturbance in the emergency department - The DORM study. Clinical Toxicology 2010;48(3):265-266. [DOI: ] - PubMed
Istikoglou 2010 {published data only}
    1. Istikoglou, C, Vlavianou, A, Foutsitzis, D, Theodorakopoulos, G, Polonifis, C, Kanellos, P, Vlissides, D. Intramuscular aripiprazole versus injectable haloperidol in treatment of acute psychotic agitation. European Neuropsychopharmacology 2010;20(SUPPL. 3):S469-S470. [DOI: ]
Jayaram 2012 {published data only}
    1. Jayaram, G, Samuels, J, Shane Konrad, S. Prediction and prevention of aggression and seclusion by early screening and comprehensive seclusion documentation. Innovations in Clinical Neuroscience 2012;9(7-8):30-38. - PMC - PubMed
Kasinathan 2015 {published data only}
    1. Kasinathan, J, Marsland, C, Batterham, P, Gaskin, C, Adams, J, Daffern, M. Assessing the risk of imminent aggression in mentally ill young offenders.. Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists 2015;23(1):44-48. - PubMed
Kim 2012 {published data only}
    1. Kim, SC, Ideker, K, Todicheeney-Mannes, D. Usefulness of aggressive behaviour risk assessment tool for prospectively identifying violent patients in medical and surgical units. Journal of Advanced Nursing 2012;68(2):349-357. [DOI: 10.1111/j.1365-2648.2011.05744.x] - DOI - PubMed
Lenox 1992 {published data only}
    1. Lenox, RH, Newhouse, PA, Creelman, WL, Whitaker, TM. Adjunctive treatment of manic agitation with lorazepam versus haloperidol: a double-blind study. The Journal of Clinical Psychiatry 1992;53(2):47-52. - PubMed
McAllister Williams 2005 {published data only}
    1. McAllister-Williams, RH. Intramuscular haloperidol-promethazine sedates violent or agitated patients more quickly than intramuscular lorazepam. Evidence Based Mental Health 2005;8(1):7-7. - PubMed
Meehan 2006 {published data only}
    1. Meehan, T, Fjeldsoe, K, Stedman, T, Duraiappah, V. Reducing aggressive behaviour and staff injuries: A multi-strategy approach. Australian Health Review: A Publication of the Australian Hospital Association 2006;30(2):203-210. - PubMed
Nau 2010 {published data only}
    1. Nau, J, Halfens, R, Needham, I, Dassen, T. Student nurses' de-escalation of patient aggression: A pretest-posttest intervention study. International Journal of Nursing Studies 2010;47(6):699-708. - PubMed
Nobay 2004 {published data only}
    1. Nobay, F, Simon, BC, Levitt, MA, Dresden, GM. A prospective, double-blind, randomized trial of midazolam versus haloperidol versus lorazepam in the chemical restraint of violent and severely agitated patients. Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 2004;11(7):744-749. - PubMed
Phillips 2008 {published data only}
    1. Phillips, LR. Abuse of aging caregivers: Test of a nursing intervention. ANS. Advances in Nursing Science 2008;31(2):164-181. - PubMed
Pratts 2014 {published data only}
    1. Pratts, M, Citrome, L, Grant, W, Leso, L, Opler, LA. A single-dose, randomized, double-blind, placebo-controlled trial of sublingual asenapine for acute agitation. Acta Psychiatrica Scandinavica 2014;130(1):61-68. - PubMed
Raveendran 2007a {published data only}
    1. Raveendran, NS, Tharyan, P, Alexander, J, Adams, CE, TREC-India II Collaborative Group. Rapid tranquillisation in psychiatric emergency settings in India: Pragmatic randomised controlled trial of intramuscular olanzapine versus intramuscular haloperidol plus promethazine. BMJ (Clinical Research Ed.) 2007;335(7625):865. - PMC - PubMed
Raveendran 2007b {published data only}
    1. Raveendran, N, Tharyan, P, Alexander, J, Adams, C. Rapid tranquillisation in psychiatric emergency setting in India: Pragmatic randomised controlled trial of intramuscular olanzapine versus intramuscular haloperidol plus promethazine. British Medical Journal 2007;335(7625):865-869. [DOI: 10.1136/bmj.39341.608519.BE] - DOI - PMC - PubMed
Riddell 2017 {published data only}
    1. Riddell, J, Tran, Al, Bengiamin, R, Hendey, GW, Armenian, P. Ketamine as a first-line treatment for severely agitated emergency department patients. American Journal of Emergency Medicine 2017;35(7):1000-1004. [DOI: 10.1016/j.ajem.2017.02.026] - DOI - PubMed
Risor 2017 {published data only}
    1. Risor, BW, Casper, SD, Andersen, LL, Sorensen, J. A multi-component patient-handling intervention improves attitudes and behaviors for safe patient handling and reduces aggression experienced by nursing staff: A controlled before-after study. Applied Ergonomics 2017;60(cyz, 0261412):74-82. - PubMed
Rogers 2012 {published data only}
    1. Rogers, SC, Borrup, K Parikh, C, Saleheen, H, Lapidus, G, Smith, S. Can a youth violence screening tool be used in a Pediatric Emergency Department setting? The Journal of Trauma and Acute Care Surgery 2012;73(4 Suppl 3):S243-S247. - PubMed
Rosen 1997 {published data only}
    1. Rosen, CL, Ratliff, AF, Wolfe, RE, Branney, SW, Roe, EJ, Pons, PT, . The efficacy of intravenous droperidol in the prehospital setting. Journal of Emergency Medicine 1997;15(1):13-17. [DOI: ] - PubMed
Simopoulos 1971 {published data only}
    1. Simopoulos, A, Pinto, A, Uhlenhuth, E, McGee, J. Old wine in new bottles: decreased hostility in chronic psychotic inpatients treated with diphenylhydantoin (Dilantin). In: V World Congress of Psychiatry, Ciudad de Mexico.. 1971.
Sival 2004 {published data only}
    1. Sival, RC, Duivenvoorden, HJ, Jansen, PA, Haffmans, PM, Duursma, SA, Eikelenboom, P. Sodium valproate in aggressive behaviour in dementia: A twelve-week open label follow-up study. International Journal of Geriatric Psychiatry 2004;19(4):305-312. - PubMed
Sivarajasingam 2003 {published data only}
    1. Sivarajasingam, V, Shepherd, JP, Matthews K. Effect of urban closed circuit television on assault injury and violence detection. Injury Prevention (1353-8047) 2003;9(4):312-316. - PMC - PubMed
Smith 1974 {published data only}
    1. Smith, GR, Taylor, CW, Linkous P. Haloperidol versus thioridazine for the treatment of psychogeriatric patients: A double blind clinical trial. Psychosomatics 1974;15(3):134-138.
Smith 2003 {published data only}
    1. Smith, RC. 10 mg intramuscular olanzapine reduces acute agitation in schizophrenia more effectively than lower doses. Evidence Based Mental Health 2003;6(1):27-27. - PubMed
Tariot 1998 {published data only}
    1. Tariot, PN, Erb, R, Podgorski, CA, Cox, C, Patel, S, Jakimovich, L, Irvine, C. Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. The American Journal of Psychiatry 1998;155(1):54-61. - PubMed
Tharyan 2008 {published data only}
    1. Tharyan, P. Tranquilising agitated mentally ill patients: Intramuscular haloperidol plus promethazine reduces need for additional medication or medical attention compared to olanzapine. Evidence Based Mental Health 2008;11(3):86-87. - PubMed
Thomas 1992 {published data only}
    1. Thomas, HJ, Schwartz, E, Petrilli, R. Droperidol versus haloperidol for chemical restraint of agitated and combative patients. Annals of Emergency Medicine 1992;21(4):407-413. - PubMed
Touzet 2014 {published data only}
    1. Touzet, S, Cornut, P, Fassier, J, Le Pogam, M, Burillon, C, Duclos, A. Impact of a program to prevent incivility towards and assault of healthcare staff in an ophtalmological emergency unit: Study protocol for the PREVURGO On/Off trial. BMC Health Services Research 2014;14(101088677):221. - PMC - PubMed
TREC Collaborative Group 2003 {published data only}
    1. TREC Collaborative Group. Rapid tranquillisation for agitated patients in emergency psychiatric rooms: A randomised trial of midazolam versus haloperidol plus promethazine. BMJ (Clinical Research Ed.) 2003;327(7417):708-713. - PMC - PubMed
Tyrer 2009 {published data only}
    1. Tyrer, P, Oliver-Africano, P, Romeo, R, Knapp, M, Dickens, S, Bouras, N, Ahmed, Z, Cooray, S, Deb, S, Murphy, D, Hare, M, Meade, M, Reece, B, Kramo, K, Bhaumik, S, Harley, D, Regan, A, Thomas, D, Rao, B, Karatela, S. Neuroleptics in the treatment of aggressive challenging behaviour for people with intellectual disabilities: A randomised controlled trial (NACHBID). Health Technology Assessment 2009;13(37):1-76. [DOI: 10.3310/hta13210] - DOI - PubMed
Veser 2002 {published data only}
    1. Veser, F, Zealburg, J, Veser, B, Zhu, Y, Gharabawi, G. Oral risperidone in the management of agitated behavior in emergency settings. European Neuropsychopharmacology; 15th International Congress of the European College of Neuropsychopharmacology, October 5-9, Barcelona, Spain 2002;12(Suppl 3):S313.
Villari 2008 {published data only}
    1. Villari, V, Rocca, P, Fonzo, V, Montemagni, C, Pandullo, P, Bogetto, F, . Oral risperidone, olanzapine and quetiapine versus haloperidol in psychotic agitation. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2008;32(2):405-413. - PubMed
Waraich 2004 {published data only}
    1. Waraich, PS. Midazolam sedates agitated patients more rapidly than haloperidol-promethazine. Evidence Based Mental Health 2004;7(2):42-42. - PubMed
Wingenfeld 2011 {published data only}
    1. Wingenfeld, K, Seidl, N, Ammann, A. Preventing disruptive behavior of nursing home residents. Zeitschrift fur Gerontologie und Geriatrie 2011;44(1):27-32. [DOI: 10.1007/s00391-010-0154-1] - DOI - PubMed
Yoon 2017 {published data only}
    1. Yoon, SJ, Choi, Seong H, Na, HR, Park, K, Kim, E, Han, HJ, Lee, J, Shim, YS, Na, DL, . Effects on agitation with rivastigmine patch monotherapy and combination therapy with memantine in mild to moderate Alzheimer's disease: A multicenter 24-week prospective randomized open-label study (the Korean EXelon Patch and combination with mEmantine Comparative Trial study). Geriatrics & Gerontology International 2017;17(3):494-499. - PubMed

Additional references

Ahmed 2010
    1. Ahmed, U, Jones, H, Adams, CE. Chlorpromazine for psychosis induced aggression or agitation. Cochrane Database of Systematic Reviews 2010, Issue 4. [DOI: 10.1002/14651858.CD007445.pub2] - DOI - PMC - PubMed
Alameddine 2015
    1. Alameddine, M, Mourad, Y, Dimassi, H. A national study on nurses’ exposure to occupational violence in Lebanon: prevalence, consequences and associated factors. PLOS ONE 2015;10(9):1-15. [DOI: 10.1371/journal.pone.0137105] - DOI - PMC - PubMed
Almvik 2000
    1. Almvik, R, Woods, P, Rasmussen, K. The Broset Violence Checklist; sensitivity, specificity and interrater reliability. J Interpers Violence 2000;15:1284–1296.
Baars 2006
    1. Baars, VA. The scale of danger [De schaal voor gevaar]. In: Mulder CL, Snijdewind A, editors(s). De Epidemie van Dwangtoepassingen in de Psychiatrie. Mension, 2006.
Baillon 2018
    1. Baillon, SF, Narayana, U, Luxenberg, JS, Clifton AV. Valproate preparations for agitation in dementia. Cochrane Database of Systematic Reviews 2018, Issue 10. [DOI: 10.1002/14651858.CD003945.pub4] - DOI - PMC - PubMed
Bandura 1976
    1. Bandura, A. Analysis of delinquency and aggression. In: Ribes-Inesta, E, Bandura, A, editors(s). Social Learning Analysis of Aggression. Oxford (UK): Lawrence Erlbaum, 1976.
Barling 2009
    1. Barling, J, Dupré, KE, Kelloway, EK. Predicting workplace aggression and violence. Annual Review of Psychology 2009;60:671-692. - PubMed
Buckley 2011
    1. Buckley, P, Cookson, H. Violence at Work: Findings from the 2010/11 British Crime Survey. London: HSE, 2011.
Camerino 2008
    1. Camerino, D, Estryn-Behar, M, Conway, PM, Van der Heijden, BI, Hasselhorn, HM. Work-related factors and violence among nursing staff in the European NEXT study: a longitudinal cohort study. International Journal of Nursing Studies 2008;45(1):35–50. - PubMed
Campbell 2001
    1. Campbell, MK, Mollison, J, Grimshaw, JM. Cluster trials in implementation research: estimation of intracluster correlation coefficients and sample size. Statistics in Medicine 2001;20(3):391-399. - PubMed
Campeau 2008
    1. Campeau, A. The space-control theory of paramedic scene-management. Symbolic Interaction 2008;31(3):285-302. [DOI: 10.1525/si.2008.31.3.285] - DOI
CDC 2014
    1. CDC. Occupational Violence. www.cdc.gov/niosh/topics/violence/traumaviol_research.html (accessed 14 November 2014).
Cooper 2002
    1. Cooper, CL, Swanson, N. Workplace Violence in the Health Sector: State of the Art. Geneva: ILO/ICN/WHO/PSI Joint Programme on Workplace Violence in the Health Sector, 2002.
Di Martino 2003
    1. Di Martino, V. Relationship between Work Stress and Workplace Violence in the Health Sector. Geneva: ILO/ICN/WHO/PSI Joint Programme on Workplace Violence in the Health Sector, 2003.
Dupré 2014
    1. Dupré, KE, Dawe, K, Barling, J. Harm to those who serve: effects of direct and vicarious customer-initiated workplace aggression. Journal of Interpersonal Violence 2014;29(13):2355-2377. [DOI: 10.1177/0886260513518841] - DOI - PubMed
Ford 2010
    1. Ford, K, Byrt, R, Dooher, R. Preventing and Reducing Aggression and Violence in Health and Social Care – A Holistic Approach. Keswick: M&K Publishing, 2010.
Gates 2011
    1. Gates, D, Gillespie, G, Smith, C, Rode, J, Kowalenko, T, Smith, B. Using action research to plan a violence prevention program for emergency departments. Journal of Emergency Nursing 2011;37(1):32-39. [DOI: ] - PubMed
Gaynes 2016
    1. Gaynes, BN, Brown, C, Lux, LJ, Brownley, K, Van Dorn, R, Edlund, M, et al. AHRQ Comparative Effectiveness Reviews: Strategies to De-escalate Aggressive Behavior in Psychiatric Patients. Rockville (MD): Agency for Healthcare Research and Quality, 2016. - PubMed
Gillen 2017
    1. Gillen, PA, Sinclair, M, Kernohan, WG, Begley, CM, Luyben, AG. Interventions for prevention of bullying in the workplace. Cochrane Database of Systematic Reviews 2017, Issue 1. [DOI: 10.1002/14651858.CD009778.pub2] - DOI - PMC - PubMed
Gillespie 2010
    1. Gillespie, GL, Gates, DM, Miller, M, Howard, PK. Workplace violence in healthcare settings: risk factors and protective strategies. Rehabilitation Nursing 2010;35(5):177-184. - PMC - PubMed
GRADEpro GDT 2015 [Computer program]
    1. GRADEpro GDT: GRADEpro Guideline Development Tool. Evidence Prime, Inc. McMaster University, 2015.
Haddon 1980
    1. Haddon, W. Advances in the epidemiology of injuries as a basis for public policy. Public Health Reports 1980;95(5):411-421. - PMC - PubMed
Harrell 2011
    1. Harrell, E. Workplace Violence, 1993-2009: National Crime Victimization Survey and the Census of Fatal Occupational Injuries. Washington: Bureau of Justice Statistics, 2011.
Hassard 2019
    1. Hassard, J, Teoh, KR, Cox, T. Estimating the economic burden posed by work-related violence to society: A systematic review of cost-of-illness studies. Safety Science 2019;116:208-221. [DOI: ]
Hershcovis 2010
    1. Hershcovis, SM, Barling, J. Towards a multi-foci approach to workplace aggression: a meta-analytic review of outcomes from different perpetrators. Journal of Organizational Behaviour 2010;31(1):24-44. [DOI: 10.1002/job] - DOI
Higgins 2011
    1. Higgins, JP, Green, S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
Hills 2013
    1. Hills, DJ, Joyce, CM. A review of research on the prevalence, antecedents, consequences and prevention of workplace aggression in clinical medical practice. Aggression and Violent Behavior 2013;18:554–569.
Hills 2014
    1. Hills, DJ, Joyce, CM. Workplace aggression in clinical medical practice: associations with job satisfaction, life satisfaction and self-rated health. Medical Journal of Australia 2014;201(9):535-540. - PubMed
Hills 2015
    1. Hills, DJ, Ross, HM, Pich, J, Hill, AT, Dalsbø, TK, Riahi, S, et al. Education and training for preventing and minimising workplace aggression directed toward healthcare workers. Cochrane Database of Systematic Reviews 2015, Issue 9. [DOI: 10.1002/14651858.CD011860] - DOI - PMC - PubMed
HSE 2016
    1. HSE. Violence at Work, 2014/15: Findings from the Crime Survey for England and Wales and from RIDDOR. London: HSE, 2016.
Huband 2010
    1. Huband, N, Ferriter, M, Nathan, R, Jones, H. Antiepileptics for aggression and associated impulsivity. Cochrane Database of Systematic Reviews 2010, Issue Issue 2. [DOI: 10.1002/14651858.CD003499.pub3] - DOI - PMC - PubMed
Huf 2016
    1. Huf, G, Alexander, J, Gandhi, P, Allen, MH. Haloperidol plus promethazine for psychosis‐induced aggression. Cochrane Database of Systematic Reviews 2016, Issue 11. [DOI: 10.1002/14651858.CD005146.pub3] - DOI - PMC - PubMed
Kennedy 2003
    1. Kennedy, JA. Mastering the Kennedy Axis V: A New Psychiatric Assessment of Patient Functioning. American Psychiatric Publishing, 2003.
Khokhar 2016
    1. Khokhar, MA, Rathbone, J. Droperidol for psychosis‐induced aggression or agitation. Cochrane Database of Systematic Reviews 2016, Issue 12. [DOI: 10.1002/14651858.CD002830.pub3] - DOI - PMC - PubMed
Kvas 2014
    1. Kvas, A, Seljak, J. Unreported workplace violence in nursing. International Nursing Review 2014;61(3):344–351. [DOI: 10.1111/inr.12106] - DOI - PubMed
Liu 2013
    1. Liu, J, Lewis, G, Evans L. Understanding aggressive behavior across the life span. Journal of Psychiatric and Mental Health Nursing 2013;20(2):156–168. [DOI: 10.1111/j.1365-2850.2012.01902.x.] - DOI - PMC - PubMed
Livingstone 2015
    1. Livingstone, N, Macdonald, G, Williams, K, Caldwell, DM, Baker, LB, Hazell, P. Pharmacological intervention for irritability, aggression, and self‐injury in Autism Spectrum Disorders (ASD). Cochrane Database of Systematic Reviews 2015, Issue 7. [DOI: 10.1002/14651858.CD011769] - DOI - PMC - PubMed
Maguire 2002
    1. Maguire, BJ, Hunting, KL, Smith, GS, Levick, NR. Occupational fatalities in emergency medical services: a hidden crisis. Annals of Emergency Medicine 2002;40(6):625-632. - PubMed
Maguire 2004
    1. Maguire, BJ, Hunting, KL, Guidotti, TL, Smith, GS. The Epidemiology of Occupational Injuries and Illnesses Among Emergency Medical Services Personnel: Dissertation. Ann Arbor (USA): ProQuest Dissertations Publishing, 2004. [UMI Number: 3121121]
Maguire 2005
    1. Maguire, BJ, Hunting, KL, Guidotti, TL, Smith, GS. Occupational injuries among emergency medical services personnel. Prehospital Emergency Care 2005;9(4):405-411. - PubMed
Martinez 2016
    1. Martinez, A. Managing workplace violence with evidence-based interventions: A literature review. Journal of Psychosocial Nursing & Mental Health Services 2016;54(9):31-36. - PubMed
Martinón‐Torres 2004
    1. Martinón‐Torres, G, Fioravanti, M, Grimley Evans, J. Trazodone for agitation in dementia. Cochrane Database of Systematic Reviews 2004, Issue 3. [DOI: 10.1002/14651858.CD004990] - DOI - PubMed
May 2009
    1. May, CR, Mair, F, Finch, T, MacFarlane, A, Dowrick, C, Treweek, S, et al. Development of a theory of implementation and integration: Normalization Process Theory. Implementation Science 2009;4(29):1-9. [DOI: 10.1186/1748-5908-4-29] - DOI - PMC - PubMed
Merecz 2006
    1. Merecz, D, Rymaszewska, J, Mościcka, A, Kiejna, A, Jarosz-Nowak, J. Violence at the workplace- a questionnaire survey of nurses. European Psychiatry 2006;21(7):442-450. - PubMed
Moher 2009
    1. Moher, D, Liberati, A, Tetzlaff, J, Altman, DG, The PRISMA Group. Preferred Reporting Items for Systematic Reviews and MetaAnalyses: The PRISMA Statement. PLoS Med 2009;6(7):e1000097. [DOI: 10.1371/journal.pmed1000097] - DOI - PMC - PubMed
NICE 2015
    1. NICE. Violence and Aggression: Short-term Management in Mental Health, Health and Community Settings. London: NICE, 2015. [ISBN:978-1-4731-1234-6] - PubMed
Nowrouzi 2016
    1. Nowrouzi, B, Huynh, V. Citation analysis of workplace violence: A review of the top 50 annual and lifetime cited articles. Aggression and Violent Behavior 2016;28(1):21-28.
Ostinelli 2018a
    1. Ostinelli, EG, Hussein, M, Ahmed, U, Rehman, FU, Miramontes, K, Adams, CE. Risperidone for psychosis‐induced aggression or agitation (rapid tranquillisation). Cochrane Database of Systematic Reviews 2018, Issue 4. [DOI: 10.1002/14651858.CD009412.pub2] - DOI - PMC - PubMed
Ostinelli 2017
    1. Ostinelli, EG, Brooke‐Powney, MJ, Li, X, Adams, CE. Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation). Cochrane Database of Systematic Reviews 2017, Issue 7. [DOI: 10.1002/14651858.CD009377.pub3] - DOI - PMC - PubMed
Ostinelli 2018b
    1. Ostinelli, EG, Jajawi, S, Spyridi, S, Sayal, K, Jayaram, MB. Aripiprazole (intramuscular) for psychosis‐induced aggression or agitation (rapid tranquillisation). Cochrane Database of Systematic Reviews 2018, Issue 1. [DOI: 10.1002/14651858.CD008074.pub2] - DOI - PMC - PubMed
Overall 1988
    1. Overall, JE, Gorham, DR. The Brief Psychiatric Rating Scale (BPRS): Recent developments in ascertainment and scaling. Pharmacopsychiatry 1988;24:97-99.
Paoli 2001
    1. Paoli, P, Merllié, D. Third European Survey on Working Conditions 2000. Luxembourg: European Foundation for the Improvement of Living and Working Conditions, 2001. [ISBN: 92-897-0130-7]
Piquero 2013
    1. Piquero, NL, Piquero, AR, Craig, JM, Clipper, SJ. Assessing research on workplace violence, 2000–2012. Aggression and Violent Behavior 2013;18(3):383–394.
Ramacciati 2016
    1. Ramacciati, N, Ceccagnoli, A, Addey, B, Lumini, E, Rasero, L. Interventions to reduce the risk of violence toward emergency department staff: Current approaches. Open Access Emergency Medicine 2016;8:17-27. - PMC - PubMed
Review Manager 2014 [Computer program]
    1. Review Manager 5 (RevMan 5). Version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
Runyan 2000
    1. Runyan, CW, Zakocs, RC, Zwerling, C. Administrative and behavioral interventions for workplace violence prevention. American Journal of Preventive Medicine 2000;18(4):116-127. - PubMed
Ryan 2013
    1. Ryan, R, Hill, S, Prictor, M, McKenzie, J. Study Quality Guide. Cochrane Consumers and Communication Review Group, 2013. - PubMed
SA Health 2016
    1. SA Health. Keep Your Hands Off our Ambos! www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+internet... (accessed 12 November 2016).
Seitz 2011
    1. Seitz, DP, Adunuri, N, Gill, SS, Gruneir, A, Herrmann, N, Rochon, P. Antidepressants for agitation and psychosis in dementia. Cochrane Database of Systematic Reviews 2011, Issue 2. [DOI: 10.1002/14651858.CD008191.pub2] - DOI - PMC - PubMed
Spector 2014
    1. Spector, PE, Zhou, ZE, Che, XX. Nurse exposure to physical and nonphysical violence, bullying, and sexual harassment: A quantitative review. International Journal of Nursing Studies 2014;51(1):72-84. - PubMed
Speroni 2014
    1. Speroni, KG, Fitch, T, Dawson, E, Dugan, L, Atherton, M. Incidence and cost of nurse workplace violence perpetrated by hospital patients or patient visitors. Journal of Emergency Nursing 2014;40(3):218-228. [DOI: 10.1016/j.jen.2013.05.014] - DOI - PubMed
Verbeek 2012
    1. Verbeek, J, Ruotsalainen, J, Hoving, JL. Synthesizing study results in a systematic review. Scandinavian Journal of Work, Environment & Health 2012;38(3):282-290. [PMID: ] - PubMed
Victorian Auditor‐General’s Office 2015
    1. Victorian Auditor-General’s Office (VAGO). Occupational Violence Against Healthcare Workers. Melbourne: VAGO, 2015. [ISBN: 978 1 925226 19 5]
Wassell 2009
    1. Wassell, JT. Workplace violence intervention effectiveness: A systematic literature review. Safety Science 2009;47(8):1049–1055.
Wistedt 1990
    1. Wistedt, B, Rasmussen, A, Pedersen, L, Malm, U, Traskman-Bendz, L, Wakelin, J, et al. The development of an observer-scale for measuring social dysfunction and aggression. Pharmacopsychiatry 1990;23:249–252. - PubMed
Zaman 2017
    1. Zaman, H, Sampson, SJ, Beck, AL, Sharma, T, Clay, FJ, Spyridi, S, Zhao, S, Gillies, D. Benzodiazepines for psychosis‐induced aggression or agitation. Cochrane Database of Systematic Reviews 2017, Issue 12. [DOI: 10.1002/14651858.CD003079.pub4] - DOI - PMC - PubMed

References to other published versions of this review

Spelten 2017
    1. Spelten, E, Thomas, B, O'Meara, PF, Maguire, BJ, FitzGerald, D, Begg SJ. Organisational interventions for preventing and minimising aggression directed toward healthcare workers by patients and patient advocates. Cochrane Database of Systematic Reviews 2017, Issue 5. [DOI: 10.1002/14651858.CD012662] - DOI - PMC - PubMed