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. 2020 Jun:95:376-383.
doi: 10.1016/j.ijid.2020.04.065. Epub 2020 Apr 27.

Coronavirus disease 2019 in pregnancy

Xu Qiancheng  1 , Shen Jian  2 , Pan Lingling  3 , Huang Lei  2 , Jiang Xiaogan  1 , Lu Weihua  1 , Yang Gang  4 , Li Shirong  4 , Wang Zhen  1 , Xiong GuoPing  5 , Zha Lei  6 ; sixth batch of Anhui medical team aiding Wuhan for COVID-19
Affiliations

Coronavirus disease 2019 in pregnancy

Xu Qiancheng et al. Int J Infect Dis. 2020 Jun.

Abstract

Objectives: This study aimed to compare clinical courses and outcomes between pregnant and reproductive-aged non-pregnant women with COVID-19, and to assess the vertical transmission potential of COVID-19 in pregnancy.

Methods: Medical records of pregnant and reproductive-aged non-pregnant women hospitalized with COVID-19 from January 15 to March 15, 2020 were retrospectively reviewed. The severity of disease, virus clearance time, and length of hospital stay were measured as the primary objective, while the vertical transmission potential of COVID-19 was also assessed.

Results: Eighty-two patients (28 pregnant women, 54 reproductive-aged non-pregnant women) with laboratory-confirmed COVID-19 were enrolled in this study. Univariate regression indicated no association between pregnancy and severity of disease (OR 0.73, 95% CI 0.08-5.15; p=0.76), virus clearance time (HR 1.16, 95% CI 0.65-2.01; p=0.62), and length of hospital stay (HR 1.10, 95% CI 0.66-1.84; p=0.71). Of the pregnant women, 22 delivered 23 live births, either by cesarean section (17, 60.7%) or vaginal delivery (5, 17.9%), and no neonate was infected with SARS-CoV-2.

Conclusions: Pregnant women have comparable clinical courses and outcomes with reproductive-aged non-pregnant women when infected with SARS-CoV-2. No evidence supported vertical transmission of COVID-19 in the late stage of pregnancy, including vaginal delivery.

Keywords: COVID-19; SARS-CoV-2; clinical feature; infection; pregnancy; virus.

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Figures

Fig. 1
Fig. 1
Flow chart of the study inclusion process.
Fig. 2
Fig. 2
Kaplan-Meier curves and log-rank tests for length of hospital stay and virus clearance time in pregnant and reproductive-aged non-pregnant women with coronavirus disease 2019 (COVID-19).
See this image and copyright information in PMC

Comment in

  • Coronavirus disease 2019 in pregnancy.
    Tang M, Zhang H, Cai J. Tang M, et al. Int J Infect Dis. 2021 Apr;105:721. doi: 10.1016/j.ijid.2021.03.027. Epub 2021 Mar 15. Int J Infect Dis. 2021. PMID: 33737127 Free PMC article. No abstract available.

References

    1. Chen H., Guo J., Wang C., Luo F., Yu X., Zhang W. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet (London, England) 2020;395(10226):809–815. - PMC - PubMed
    1. Chen L., Li Q., Zheng D., Jiang H., Wei Y., Zou L. Clinical characteristics of pregnant women with Covid-19 in Wuhan, China. The New England journal of medicine. 2020 - PMC - PubMed
    1. Creanga A.A., Johnson T.F., Graitcer S.B., Hartman L.K., Al-Samarrai T., Schwarz A.G. Severity of 2009 pandemic influenza A (H1N1) virus infection in pregnant women. Obstetrics and gynecology. 2010;115(4):717–726. - PubMed
    1. Cucinotta D., Vanelli M. WHO Declares COVID-19 a Pandemic. Acta bio-medica: Atenei Parmensis. 2020;91(1):157–160. - PMC - PubMed
    1. Hiratsuka M., Minakami H., Koshizuka S., Sato I. Administration of interferon-alpha during pregnancy: effects on fetus. Journal of perinatal medicine. 2000;28(5):372–376. - PubMed