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Review
. 2020 May-Jun;34(3):953-964.
doi: 10.21873/invivo.11863.

Pathophysiological Changes During Ischemia-reperfusion Injury in Rodent Hepatic Steatosis

Anna-Aikaterini Neri  1 , Ismene A Dontas  2 , Dimitrios C Iliopoulos  3 , Theodore Karatzas  3   4
Affiliations
Review

Pathophysiological Changes During Ischemia-reperfusion Injury in Rodent Hepatic Steatosis

Anna-Aikaterini Neri et al. In Vivo. 2020 May-Jun.

Abstract

Background/aim: Ischemia and reperfusion injuries may produce deleterious effects on hepatic tissue after liver surgery and transplantation. The impact of ischemia-reperfusion injury (IRI) on the liver depends on its substrate, the percentage of liver ischemic tissue subjected to IRI and the ischemia time. The consequences of IRI are more evident in pathologic liver substrates, such as steatotic livers. This review is the result of an extended bibliographic PubMed search focused on the last 20 years. It highlights basic differences encountered during IRI in lean and steatotic livers based on studies using rodent experimental models.

Conclusion: The main difference in cell death between lean and steatotic livers is the prevalence of apoptosis in the former and necrosis in the latter. There are also major changes in the effect of intracellular mediators, such as TNFα and IL-1β. Further experimental studies are needed in order to increase current knowledge of IRI effects and relevant mechanisms in both lean and steatotic livers, so that new preventive and therapeutic strategies maybe developed.

Keywords: Liver injury; cytokines; hepatic steatosis; ischemia-reperfusion injury; oxidative stress; pathophysiological changes; review.

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Conflict of interest statement

The Authors report no conflicts of interest regarding this study.

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