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Review
. 2020 May-Jun;34(3):1283-1288.
doi: 10.21873/invivo.11903.

Salvage Re-irradiation Options in Adult Medulloblastoma: A Case Report and Review of the Literature

Francesco Cuccia  1   2 , Gianluca Mortellaro  3 , Lucia Ognibene  4 , Giuseppe Craparo  5 , Antonio Lo Casto  6 , Giuseppe Ferrera  3
Affiliations
Review

Salvage Re-irradiation Options in Adult Medulloblastoma: A Case Report and Review of the Literature

Francesco Cuccia et al. In Vivo. 2020 May-Jun.

Abstract

Background/aim: Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage re-irradiation collecting very heterogeneous series.

Case report: A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease.

Conclusion: Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.

Keywords: Medulloblastoma; adult patients; re-irradiation.

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Conflict of interest statement

The Authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Preoperative brain MRI in T1-weighted contrast enhanced (right) and T2-weighted (left) sequence
Figure 2
Figure 2. Brain MRI in T1-weighted contrast enhanced before stereotactic radiotherapy (left) and after 14 months (right)
See this image and copyright information in PMC

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