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Comment
. 2020 May 1;5(1):49.
doi: 10.1038/s41392-020-0154-6.

Igniting autophagy through the regulation of phase separation

Shouheng Jin  1 , Jun Cui  2
Affiliations
Comment

Igniting autophagy through the regulation of phase separation

Shouheng Jin et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Phase separation ignites autophagy. Under autophagy-inducible conditions, decreased TORC1 activity promotes the dephosphorylation of Atg13 by PP2C, leading to the formation of the Atg1 complex. The Atg1 complex then undergoes phase separation to generate an early PAS, which is tethered to the vacuolar membrane via Vac8. The liquid droplet induces the autophosphorylation of the Atg1 kinase, which subsequently recruits downstream Atg proteins, thus prompting the formation of autophagosomes
See this image and copyright information in PMC

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