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Case Reports
. 2020 Apr 9;13(1):403-407.
doi: 10.1159/000506675. eCollection 2020 Jan-Apr.

Renal Squamous Cell Carcinoma with Staghorn Calculus

Ryo Kasahara  1 , Takashi Kawahara  2 , Ryosuke Tajiri  3 , Hiroji Uemura  2 , Kazuo Kitami  1
Affiliations
Case Reports

Renal Squamous Cell Carcinoma with Staghorn Calculus

Ryo Kasahara et al. Case Rep Oncol. .

Abstract

A 70-year-old Japanese woman was referred to our department due to general fatigue and a persistent low fever. We performed percutaneous nephrostomy and administered antibiotics for the pyelonephritis due to her left staghorn calculus. After the infection had been brought under control and her general condition improved, we performed nephrectomy. A pathologic examination revealed renal squamous cell carcinoma (SCC) in addition to xanthogranulomatous inflammation. Seventeen days after the operation, computed tomography demonstrated local recurrence of the tumor; therefore, she received palliative care. Two months after her operation, she died of renal SCC.

Keywords: Pyelonephritis; Renal squamous cell carcinoma; Staghorn calculus.

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Conflict of interest statement

We declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
a Abdominal CT showed that the left renal pelvis was occupied by a staghorn calculus. b Percutaneous nephrostomy was performed.
Fig. 2
Fig. 2
a CT revealed that the middle and inferior calyxes were not drained adequately. b Two additional nephrostomies were performed.
Fig. 3
Fig. 3
Nephrectomy was performed, and the kidney was divided into two pieces.
Fig. 4
Fig. 4
a, b HE staining; squamous cell carcinoma accompanied by a cancer pearl. Immunohistochemical staining was negative for GATA3 (c) and P40 (d) and positive for CK5/6 (e).
Fig. 5
Fig. 5
a CT revealed local recurrence with rapid enlargement occupying the abdomen (b).
See this image and copyright information in PMC

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