Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep;122(3):495-505.
doi: 10.1002/jso.25966. Epub 2020 Apr 30.

Time trends and predictors of survival in surgically resected early-stage non-small cell lung cancer patients

Jitesh B Shewale  1   2 , Erin M Corsini  1 , Arlene M Correa  1 , Eric L Brown  2 , Luis G Leon-Novelo  3 , Alan G Nyitray  2   4 , Mara B Antonoff  1 , Wayne L Hofstetter  1 , Reza J Mehran  1 , David C Rice  1 , Jack Roth  1 , Garrett L Walsh  1 , Ara A Vaporciyan  1 , Stephen G Swisher  1 , Boris Sepesi  1
Affiliations

Time trends and predictors of survival in surgically resected early-stage non-small cell lung cancer patients

Jitesh B Shewale et al. J Surg Oncol. 2020 Sep.

Abstract

Background: The improvement in the management of lung cancer have the potential to improve survival in patients undergoing resection for early-stage (stage I and II) non-small cell lung cancer (NSCLC), but few studies have evaluated time trends and identified predictors of overall survival (OS).

Methods: We identified surgically resected early-stage NSCLC between 1998 and 2016. The 3-year OS (1998-2014) and 5-year OS (1998-2012) rates were calculated for each year. Joinpoint regression was used to calculate annual percentage changes (APC) and to test time trends in OS. Multivariable Cox regression was used to identify predictors of OS.

Results: There was a significant upward trend in the 3-year (1998, 56%; 2014, 83%; APC = 1.8) and 5-year (1998, 47%; 2012, 76%; APC = 3.1) OS. Older age; male sex; history of diabetes, coronary artery disease, and chronic obstructive pulmonary disease; high ASA score; smoking pack-years; high-grade tumor; pneumonectomy; thoracotomy; neoadjuvant therapy; nodal disease; and positive tumor margin were predictors of poor OS.

Conclusion: The upward time trend in OS suggests that improved staging, patient selection, and management have conferred a survival benefit in early-stage NSCLC patients. The prediction model of OS could be used to refine selection criteria for resection and improve survival outcomes.

Keywords: early-stage NSCLC; lung resection; nomogram; overall survival; prediction model; temporal trend.

PubMed Disclaimer

References

REFERENCES

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics. CA. 2019;69(1):7-34. Jan.
    1. Scott WJ, Howington J, Feigenberg S, et al. Treatment of non-small cell lung cancer stage I and stage II: ACCP evidence-based clinical practice guidelines. Chest. 2007;132(3):234S-242SS.
    1. Moyer VA. Screening for lung cancer: US Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;160(5):330-338.
    1. Howlader N, Noone AM, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2016, National Cancer Institute. Bethesda, MD. https://seer.cancer.gov/csr/1975_2016/, based on November 2018 SEER data submission, posted to the SEER web site, April 2019.
    1. Jemal A, Thun MJ, Ries LA, et al. Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control. JNCI. 2008;100(23):1672-1694.

MeSH terms

LinkOut - more resources