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Multicenter Study
. 2020 Jul 9;383(2):185-187.
doi: 10.1056/NEJMc2008646. Epub 2020 May 1.

Early Detection of Covid-19 through a Citywide Pandemic Surveillance Platform

Helen Y Chu  1 , Janet A Englund  2 , Lea M Starita  3 , Michael Famulare  4 , Elisabeth Brandstetter  5 , Deborah A Nickerson  5 , Mark J Rieder  3 , Amanda Adler  2 , Kirsten Lacombe  2 , Ashley E Kim  5 , Chelsey Graham  3 , Jennifer Logue  5 , Caitlin R Wolf  5 , Jessica Heimonen  5 , Denise J McCulloch  5 , Peter D Han  3 , Thomas R Sibley  6 , Jover Lee  6 , Misja Ilcisin  6 , Kairsten Fay  6 , Roy Burstein  4 , Beth Martin  5 , Christina M Lockwood  5 , Matthew Thompson  5 , Barry Lutz  5 , Michael Jackson  7 , James P Hughes  5 , Michael Boeckh  6 , Jay Shendure  3 , Trevor Bedford  6 ; Seattle Flu Study Investigators
Affiliations
Multicenter Study

Early Detection of Covid-19 through a Citywide Pandemic Surveillance Platform

Helen Y Chu et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Covid-19 Case Detection through the Seattle Flu Study.
Panel A shows SARS-CoV-2 tests over time, further stratified according to age group; detection of positive SARS-CoV-2 test results over time and as a percentage of the total number of tests run; and Covid-19–positive case counts over time. Panel B shows cycle threshold values from a laboratory-developed multiplex quantitative reverse-transcriptase polymerase-chain-reaction (qRT-PCR) assay as a function of days elapsed from swab collection to freezing or nucleic acid extraction for virus detection, shown separately for SARS-CoV-2, other respiratory viruses, and RNase P, a human cellular marker. The horizontal line in each box represents the median, the lower and upper boundaries of the boxes the interquartile range, and the ends of the vertical lines 1.5 times the interquartile range. Individual points represent outliers (>1.5 times the interquartile range).
See this image and copyright information in PMC

References

    1. Fink S, Baker M. “It’s just everywhere already”: how delays in testing set back the U.S. coronavirus response. New York Times. March 10, 2020. (https://www.nytimes.com/2020/03/10/us/coronavirus-testing-delays.html).
    1. Chu HY, Boeckh M, Englund JA, et al. The Seattle Flu Study: a multi-arm community-based prospective study protocol for assessing influenza prevalence, transmission, and genomic epidemiology. March 6, 2020. (https://www.medrxiv.org/content/10.1101/2020.03.02.20029595v1) (preprint). - PMC - PubMed
    1. Bedford T, Greninger AL, Roychoudhury P, et al. Cryptic transmission of SARS-CoV-2 in Washington State. April 16, 2020. (https://www.medrxiv.org/content/10.1101/2020.04.02.20051417v1) (preprint). - PMC - PubMed
    1. Klein D, Hagedorn B, Kerr C, Hu H, Bedford T, Famulare M. Working paper — model-based estimates of COVID-19 burden in King and Snohomish counties through April 7, 2020. March 10, 2020. (https://institutefordiseasemodeling.github.io/COVID-public/reports/Worki...).