Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2020 Jul 9;383(2):185-187.
doi: 10.1056/NEJMc2008646. Epub 2020 May 1.

Early Detection of Covid-19 through a Citywide Pandemic Surveillance Platform

Helen Y Chu  1 , Janet A Englund  2 , Lea M Starita  3 , Michael Famulare  4 , Elisabeth Brandstetter  5 , Deborah A Nickerson  5 , Mark J Rieder  3 , Amanda Adler  2 , Kirsten Lacombe  2 , Ashley E Kim  5 , Chelsey Graham  3 , Jennifer Logue  5 , Caitlin R Wolf  5 , Jessica Heimonen  5 , Denise J McCulloch  5 , Peter D Han  3 , Thomas R Sibley  6 , Jover Lee  6 , Misja Ilcisin  6 , Kairsten Fay  6 , Roy Burstein  4 , Beth Martin  5 , Christina M Lockwood  5 , Matthew Thompson  5 , Barry Lutz  5 , Michael Jackson  7 , James P Hughes  5 , Michael Boeckh  6 , Jay Shendure  3 , Trevor Bedford  6 ; Seattle Flu Study Investigators
Affiliations
Multicenter Study

Early Detection of Covid-19 through a Citywide Pandemic Surveillance Platform

Helen Y Chu et al. N Engl J Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Covid-19 Case Detection through the Seattle Flu Study.
Panel A shows SARS-CoV-2 tests over time, further stratified according to age group; detection of positive SARS-CoV-2 test results over time and as a percentage of the total number of tests run; and Covid-19–positive case counts over time. Panel B shows cycle threshold values from a laboratory-developed multiplex quantitative reverse-transcriptase polymerase-chain-reaction (qRT-PCR) assay as a function of days elapsed from swab collection to freezing or nucleic acid extraction for virus detection, shown separately for SARS-CoV-2, other respiratory viruses, and RNase P, a human cellular marker. The horizontal line in each box represents the median, the lower and upper boundaries of the boxes the interquartile range, and the ends of the vertical lines 1.5 times the interquartile range. Individual points represent outliers (>1.5 times the interquartile range).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

  • How We Manage Patients With Chronic Lymphocytic Leukemia During the SARS-CoV-2 Pandemic.
    Rossi D, Shadman M, Condoluci A, Brown JR, Byrd JC, Gaidano G, Hallek M, Hillmen P, Mato A, Montserrat E, Ghia P. Rossi D, et al. Hemasphere. 2020 Jul 30;4(4):e432. doi: 10.1097/HS9.0000000000000432. eCollection 2020 Aug. Hemasphere. 2020. PMID: 32803132 Free PMC article. Review.
  • Respiratory viruses in hematopoietic cell transplant candidates: impact of preexisting lower tract disease on outcomes.
    Kim YJ, Waghmare A, Xie H, Holmberg L, Pergam SA, Jerome KR, Leisenring WM, Ogimi C, Campbell AP, Englund JA, Boeckh M. Kim YJ, et al. Blood Adv. 2022 Sep 27;6(18):5307-5316. doi: 10.1182/bloodadvances.2021004915. Blood Adv. 2022. PMID: 35446933 Free PMC article.
  • Rapid and Specific Detection of Active SARS-CoV-2 With CRISPR/Cas12a.
    Liu X, Li Y, Wang X, Song Y, Wu L, Yu B, Ma X, Ma P, Liu M, Huang X, Wang X. Liu X, et al. Front Microbiol. 2022 Jan 28;12:820698. doi: 10.3389/fmicb.2021.820698. eCollection 2021. Front Microbiol. 2022. PMID: 35154046 Free PMC article.
  • Serological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreak.
    Dingens AS, Crawford KHD, Adler A, Steele SL, Lacombe K, Eguia R, Amanat F, Walls AC, Wolf CR, Murphy M, Pettie D, Carter L, Qin X, King NP, Veesler D, Krammer F, Dickerson JA, Chu HY, Englund JA, Bloom JD. Dingens AS, et al. Nat Commun. 2020 Sep 1;11(1):4378. doi: 10.1038/s41467-020-18178-1. Nat Commun. 2020. PMID: 32873791 Free PMC article.
  • Multiple early factors anticipate post-acute COVID-19 sequelae.
    Su Y, Yuan D, Chen DG, Ng RH, Wang K, Choi J, Li S, Hong S, Zhang R, Xie J, Kornilov SA, Scherler K, Pavlovitch-Bedzyk AJ, Dong S, Lausted C, Lee I, Fallen S, Dai CL, Baloni P, Smith B, Duvvuri VR, Anderson KG, Li J, Yang F, Duncombe CJ, McCulloch DJ, Rostomily C, Troisch P, Zhou J, Mackay S, DeGottardi Q, May DH, Taniguchi R, Gittelman RM, Klinger M, Snyder TM, Roper R, Wojciechowska G, Murray K, Edmark R, Evans S, Jones L, Zhou Y, Rowen L, Liu R, Chour W, Algren HA, Berrington WR, Wallick JA, Cochran RA, Micikas ME; ISB-Swedish COVID-19 Biobanking Unit; Wrin T, Petropoulos CJ, Cole HR, Fischer TD, Wei W, Hoon DSB, Price ND, Subramanian N, Hill JA, Hadlock J, Magis AT, Ribas A, Lanier LL, Boyd SD, Bluestone JA, Chu H, Hood L, Gottardo R, Greenberg PD, Davis MM, Goldman JD, Heath JR. Su Y, et al. Cell. 2022 Mar 3;185(5):881-895.e20. doi: 10.1016/j.cell.2022.01.014. Epub 2022 Jan 25. Cell. 2022. PMID: 35216672 Free PMC article.
See all "Cited by" articles

References

    1. Fink S, Baker M. “It’s just everywhere already”: how delays in testing set back the U.S. coronavirus response. New York Times. March 10, 2020. (https://www.nytimes.com/2020/03/10/us/coronavirus-testing-delays.html).
    1. Chu HY, Boeckh M, Englund JA, et al. The Seattle Flu Study: a multi-arm community-based prospective study protocol for assessing influenza prevalence, transmission, and genomic epidemiology. March 6, 2020. (https://www.medrxiv.org/content/10.1101/2020.03.02.20029595v1) (preprint). - PMC - PubMed
    1. Bedford T, Greninger AL, Roychoudhury P, et al. Cryptic transmission of SARS-CoV-2 in Washington State. April 16, 2020. (https://www.medrxiv.org/content/10.1101/2020.04.02.20051417v1) (preprint). - PMC - PubMed
    1. Klein D, Hagedorn B, Kerr C, Hu H, Bedford T, Famulare M. Working paper — model-based estimates of COVID-19 burden in King and Snohomish counties through April 7, 2020. March 10, 2020. (https://institutefordiseasemodeling.github.io/COVID-public/reports/Worki...).