Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 May;48(5):300060519896914.
doi: 10.1177/0300060519896914.

Turner syndrome with rapidly progressive puberty: a case report and literature review

Xuewen Yuan  1 , Ziyang Zhu  1
Affiliations
Review

Turner syndrome with rapidly progressive puberty: a case report and literature review

Xuewen Yuan et al. J Int Med Res. 2020 May.

Abstract

This report describes a clinically rare and atypical case of 46,X,idic(X)(q21.32)/45,X-type Turner syndrome with rapidly progressive puberty development. After 11 months of treatment with recombinant human growth hormone (rhGH), the child's height increased. After 18 months of treatment with rhGH, the child showed secondary sex characteristics. The child was followed up for 1 year after the appearance of the secondary sex characteristics, and regular menses were still present. This case indicates that modern molecular biology techniques should be used rationally to further investigate the existence of X-chromosome translocations and occult chimeras to prevent misdiagnosis.

Keywords: Turner syndrome; chromosomal abnormality; karyotype; puberty development; recombinant human growth hormone; secondary sex characteristics.

PubMed Disclaimer

References

    1. Turner HH. A syndrome of infantilism, congenital webbed neck, and cubitus valgus. Endocrinology 1938; 23: 566–574. - PubMed
    1. Stochholm K, Juul S, Juel K, et al. Prevalence, incidence, diagnostic delay, and mortality in Turner syndrome. J Clin Endocrinol Metab 2006; 91: 3897–3902. - PubMed
    1. Sybert VP, McCauley E. Turner's syndrome. N Engl J Med 2004; 351: 1227–1238. - PubMed
    1. Tarani L, Lampariello S, Raguso G, et al. Pregnancy in patients with Turner's syndrome: six new cases and review of literature. Gynecol Endocrinol 1998; 12: 83–87. - PubMed
    1. Carpini S, Carvalho AB, de Lemos-Marini SHV, et al. FSH may be a useful tool to allow early diagnosis of Turner syndrome. BMC Endocr Disord 2018; 18: 8. - PMC - PubMed