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Observational Study
. 2020 Apr 26;12(5):1225.
doi: 10.3390/nu12051225.

Changes in Nutrition Impact Symptoms, Nutritional and Functional Status during Head and Neck Cancer Treatment

May Kay Neoh  1   2 , Zalina Abu Zaid  1 , Zulfitri Azuan Mat Daud  1 , Nor Baizura Md Yusop  1 , Zuriati Ibrahim  1 , Zuwariah Abdul Rahman  2 , Norshariza Jamhuri  1   2
Affiliations
Observational Study

Changes in Nutrition Impact Symptoms, Nutritional and Functional Status during Head and Neck Cancer Treatment

May Kay Neoh et al. Nutrients. .

Abstract

Background: The purpose of this study is to evaluate changes in nutrition impact symptoms (NIS) and nutritional and functional status that occur throughout radiotherapy in head and neck cancer (HNC) patients.

Methods: A prospective observational study of HNC inpatients who underwent radiotherapy with or without chemotherapy were recruited to participate. Fifty patients were followed for the periods before, in the middle and at the end of radiotherapy. Nutritional parameters were collected throughout radiotherapy.

Results: According to Patient-Generated Subjective Global Assessment (PG-SGA), there was an increase from a baseline of 56% malnourished HNC patients to 100% malnourished with mean weight loss of 4.53 ± 0.41kg (7.39%) at the end of radiotherapy. Nutritional parameters such as muscle mass, fat mass, body mass index, dietary energy and protein intake decrease significantly (p < 0.0001) while NIS score, energy and protein intake from oral nutritional supplements (ONS) increased significantly (p < 0.0001). Hand grip strength did not differ significantly. All HNC patients experienced taste changes and dry mouth that required ONS at the end of treatment. ONS compliance affected the percentage of weight loss (p = 0.013).

Conclusions: The intensive nutritional care time point was the middle of RT. The PG-SGA and NIS checklist are useful for monitoring nutrition for HNC patients.

Keywords: dietary intake; head and neck cancer; malnutrition; nutrition impact symptoms; nutritional status; oral nutritional supplements.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the protocol.
See this image and copyright information in PMC

References

    1. Boyle P., Levin B. World Cancer Report 2008. IARC Press, International Agency for Research on Cancer; Lyon, France: 2008.
    1. Mulasi U., Vock D.M., Kuchnia A.J., Jha G., Fujioka N., Rudrapatna V., Patel M.R., Teigen L., Earthman C.P. Malnutrition Identified by the Academy of Nutrition and Dietetics and American Society for Parenteral and Enteral Nutrition Consensus Criteria and Other Bedside Tools Is Highly Prevalent in a Sample of Individuals Undergoing Treatment for Head and Neck Cancer. J. Parenter. Enter. Nutr. 2016;42:139–147. doi: 10.1177/0148607116672264. - DOI - PubMed
    1. Arribas L., Hurtós L., Milà R., Fort E., Peiró I. Predict factors associated with malnutrition from patient generated subjective global assessment (PG-SGA) in head and neck cancer patients. Nutr. Hosp. 2013;28:155–163. - PubMed
    1. Langius J.A.E., Doornaert P., Spreeuwenberg M.D., Langendijk J.A., Leemans C.R., Van Der Schueren M.A.E. Radiotherapy on the neck nodes predicts severe weight loss in patients with early stage laryngeal cancer. Radiother. Oncol. 2010 doi: 10.1016/j.radonc.2010.02.017. - DOI - PubMed
    1. Couch M., Lai V., Cannon T., Guttridge D., Zanation A., George J., Hayes N., Zeisel S., Shores C. Cancer cachexia syndrome in head and neck cancer patients: Part I.Diagnosis, impact on quality of life and survival, and treatment. Head Neck. 2007;29:401–411. doi: 10.1002/hed.20447. - DOI - PubMed

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