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Review
. 2020 Apr 26;8(2):201.
doi: 10.3390/vaccines8020201.

A Durable Relationship: Respiratory Syncytial Virus Bronchiolitis and Asthma past Their Golden Anniversary

Ignacio Esteban  1   2 , Renato T Stein  3 , Fernando P Polack  1   4
Affiliations
Review

A Durable Relationship: Respiratory Syncytial Virus Bronchiolitis and Asthma past Their Golden Anniversary

Ignacio Esteban et al. Vaccines (Basel). .

Abstract

Numerous preventive strategies against respiratory syncytial virus (RSV) are undergoing late stage evaluation in humans and, in addition to their intended benefit for acute illness, may impact long term consequences of infection in infants. Severe RSV infection has been repeatedly associated in the literature with long term complications, including impaired lung function, recurrent wheezing, and asthma. However, whether RSV lower respiratory tract infection (LRTI) causally affects the odds for developing wheezing and/or asthma during childhood requires further study, and the biological mechanisms underlying this hypothetical progression from viral illness to chronic lung disease are poorly characterized. In this review, we summarize the literature exploring the association between RSV LRTI in infancy and subsequent recurrent wheezing and pediatric asthma.

Keywords: asthma; bronchiolitis; respiratory syncytial virus; wheezing.

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Conflict of interest statement

IE declares no conflict of interest. RTS reports grants and personal fees from Novavax, personal fees from Medimmune, grants and personal fees from Janssen, and personal fees from Sanofi, all outside the submitted work. FPP reports grants and non-financial support from Novavax; personal fees from Medimmune, grants and personal fees from Janssen, personal fees from Sanofi, personal fees from Bavarian Nordic, personal fees from Pfizer, personal fees from Merck, personal fees from ArkBio, personal fees from VirBio, personal fees from Regeneron, personal fees from Daiichi Sankyo, all outside the submitted work.

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