Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun;20(6):345-346.
doi: 10.1038/s41577-020-0328-z.

COVID-19: a case for inhibiting IL-17?

Omar Pacha  1 , Mary Alice Sallman  2 , Scott E Evans  3
Affiliations

COVID-19: a case for inhibiting IL-17?

Omar Pacha et al. Nat Rev Immunol. 2020 Jun.

Abstract

IL-17 and IL-17 receptor inhibitors boast an impressive safety history and are widely available. Here, we argue that targeting IL-17 is immunologically plausible as a strategy to prevent acute respiratory distress syndrome (ARDS) in coronavirus disease 2019 (COVID-19) and discuss why we think that a clinical trial of a drug in this class could be a logical addition to the effort to find effective therapies.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. Mahallawi WH, Khabour OF, Zhang Q, Makhdoum HM, Suliman BA. MERS-CoV infection in humans is associated with a pro-inflammatory TH1 and TH17 cytokine profile. Cytokine. 2018;104:8–13. doi: 10.1016/j.cyto.2018.01.025. - DOI - PMC - PubMed
    1. Yang X, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir. Med. 2020 doi: 10.1016/S2213-2600(20)30079-5. - DOI - PMC - PubMed
    1. Mehta P, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395:1033–1034. doi: 10.1016/S0140-6736(20)30628-0. - DOI - PMC - PubMed
    1. Kudva A, et al. Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice. J. Immunol. 2010;186:1666–1674. doi: 10.4049/jimmunol.1002194. - DOI - PMC - PubMed
    1. Crowe CR, et al. Critical role of IL-17RA in immunopathology of influenza infection. J. Immunol. 2009;183:5301–5310. doi: 10.4049/jimmunol.0900995. - DOI - PMC - PubMed

Publication types