Considering BCG vaccination to reduce the impact of COVID-19

Affiliations

¹ Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Infectious Diseases Research Group, Murdoch Children's Research Institute, Parkville, VIC, Australia; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, VIC 3052, Australia. Electronic address: nigel.curtis@rch.org.au.
² The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
³ WHO, Geneva, Switzerland.
⁴ Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.

Nigel Curtis et al. Lancet. 2020.

. 2020 May 16;395(10236):1545-1546.

doi: 10.1016/S0140-6736(20)31025-4. Epub 2020 Apr 30.

¹ Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Infectious Diseases Research Group, Murdoch Children's Research Institute, Parkville, VIC, Australia; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, VIC 3052, Australia. Electronic address: nigel.curtis@rch.org.au.
² The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
³ WHO, Geneva, Switzerland.
⁴ Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.

No abstract available

References

1. Pollard AJ, Finn A, Curtis N. Non-specific effects of vaccines: plausible and potentially important, but implications uncertain. Arch Dis Child. 2017;102:1077–1081. - PubMed
1. Goodridge HS, Ahmed SS, Curtis N. Harnessing the beneficial heterologous effects of vaccination. Nat Rev Immunol. 2016;16:392–400. - PMC - PubMed
1. Biering-Sorensen S, Aaby P, Lund N. Early BCG-Denmark and neonatal mortality among infants weighing <2500 g: a randomized controlled trial. Clin Infect Dis. 2017;65:1183–1190. - PMC - PubMed
1. Nemes E, Geldenhuys H, Rozot V. Prevention of M. tuberculosis infection with H4:IC31 vaccine or BCG revaccination. N Engl J Med. 2018;379:138–149. - PMC - PubMed
1. Arts RJW, Moorlag S, Novakovic B. BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity. Cell Host Microbe. 2018;23:89–100.e5. - PubMed