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Comment
. 2020 Apr 30;181(3):514-517.
doi: 10.1016/j.cell.2020.04.005.

Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy

Jukka Westermarck  1 , Benjamin G Neel  2
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Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy

Jukka Westermarck et al. Cell. .
Free article

Abstract

Members of the PP2A family of serine/threonine phosphatases are important human tumor suppressor genes. Unlike most tumor suppressors, they are rarely mutated/deleted, but rather are impaired by "inhibitor proteins." Two papers in this issue of Cell show how some phenothiazine derivatives reactivate specific PP2A isozymes with potential benefit in cancer and other diseases.

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Conflict of interest statement

Declaration of Interests Benjamin G. Neel is the co-Founder, holds Founders equity, and receives consulting income from Navire Pharmaceuticals, which is developing SHP2 inhibitors for clinical use. He also is co-Founder, has Founders equity, and receives consulting income from Northern Biologics, Inc. He is a member of the Scientific Advisory Board and receives consulting fees and stock options from Arvinas, Inc. He has been an Expert Witness for Johnson and Johnson, Inc. in the talc litigation in U.S. Federal Court. His spouse owns equity in Arvinas, Amgen, Moderna, and Gilead Pharmaceuticals.

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