Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jun;43(6):355-357.
doi: 10.1016/j.tins.2020.04.004. Epub 2020 Apr 21.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System

Fernanda G De Felice  1 , Fernanda Tovar-Moll  2 , Jorge Moll  3 , Douglas P Munoz  4 , Sergio T Ferreira  5
Affiliations
Review

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System

Fernanda G De Felice et al. Trends Neurosci. 2020 Jun.

Abstract

Emerging evidence indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), can cause neurological complications. We provide a brief overview of these recent observations and discuss some of their possible implications. In particular, given the global dimension of the current pandemic, we highlight the need to consider the possible long-term impact of COVID-19, potentially including neurological and neurodegenerative disorders.

Keywords: COVID-19; Parkinson’s disease; anosmia; encephalitis; neurodegenerative diseases; neurological alterations.

PubMed Disclaimer

References

    1. Yang X. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir. Med. 2020 doi: 10.1016/S2213-2600(20)30079-5. Published online February 24, 2020. - DOI - PMC - PubMed
    1. Chen T. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;1091 - PMC - PubMed
    1. Mao L. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020 doi: 10.1001/jamaneurol.2020.1127. Published online April 10, 2020. - DOI - PMC - PubMed
    1. Poyiadji N. COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI Features. Radiology. 2020;2:201187. - PMC - PubMed
    1. Helms J. Neurologic features in severe SARS-CoV-2 infection. N. Engl. J. Med. 2020 doi: 10.1056/NEJMc2008597. Published online April 15, 2020. - DOI - PMC - PubMed