Anti-inflammatory principles from Lindera aggregata

Ping-Chung Kuo¹, Yi-Hung Wu², Hsin-Yi Hung¹, Sio-Hong Lam¹, Guo-Hao Ma³, Liang-Mou Kuo⁴, Tsong-Long Hwang⁵, Daih-Huang Kuo⁶, Tian-Shung Wu⁷

Affiliations

¹ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
² Hsinhua Forest Station, The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan.
³ Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
⁴ Department of General Surgery, Chang Gung Memorial Hospital at Chiayi, Chiayi 613, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
⁵ Graduate Institute of Natural Products, College of Medicine, Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Industry of Human Ecology, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.
⁶ Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan.
⁷ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan. Electronic address: tswu@mail.ncku.edu.tw.

PMID: 32359855
DOI: 10.1016/j.bmcl.2020.127224

Anti-inflammatory principles from Lindera aggregata

Ping-Chung Kuo et al. Bioorg Med Chem Lett. 2020.

. 2020 Jul 1;30(13):127224.

doi: 10.1016/j.bmcl.2020.127224. Epub 2020 Apr 27.

Authors

Ping-Chung Kuo¹, Yi-Hung Wu², Hsin-Yi Hung¹, Sio-Hong Lam¹, Guo-Hao Ma³, Liang-Mou Kuo⁴, Tsong-Long Hwang⁵, Daih-Huang Kuo⁶, Tian-Shung Wu⁷

Affiliations

¹ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
² Hsinhua Forest Station, The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan.
³ Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
⁴ Department of General Surgery, Chang Gung Memorial Hospital at Chiayi, Chiayi 613, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
⁵ Graduate Institute of Natural Products, College of Medicine, Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Industry of Human Ecology, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.
⁶ Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan.
⁷ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan. Electronic address: tswu@mail.ncku.edu.tw.

PMID: 32359855
DOI: 10.1016/j.bmcl.2020.127224

Abstract

Four new sesquiterpenes (1-4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC₅₀ values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

Keywords: Alkaloid; Anti-inflammatory; Benzenoid glycoside; Elastase release; Sesquiterpene; Superoxide anion generation.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Anti-inflammatory principles from Lindera aggregata

Affiliations

Anti-inflammatory principles from Lindera aggregata

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources