Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Herman Autrup¹, Frank A Barile², Sir Colin Berry³, Bas J Blaauboer⁴, Alan Boobis⁵, Herrmann Bolt⁶, Christopher J Borgert⁷, Wolfgang Dekant⁸, Daniel Dietrich⁹, Jose L Domingo¹⁰, Gio Batta Gori¹¹, Helmut Greim¹², Jan Hengstler⁶, Sam Kacew¹³, Hans Marquardt¹⁴, Olavi Pelkonen¹⁵, Kai Savolainen¹⁶, Pat Heslop-Harrison¹⁷, Nico P Vermeulen¹⁸

Affiliations

¹ Institute of Public Health, University of Aarhus, Aarhus, Denmark.
² College of Pharmacy and Health Sciences, St John's University, Queens, NY, USA.
³ Queen Mary University of London, UK.
⁴ Division of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
⁵ National Heart & Lung Institute, Imperial College, London, UK.
⁶ Leibniz Research Centre for Working Environment and Human Factors (IfADo), TU Dortmund, Dortmund, Germany.
⁷ Applied Pharmacology and Toxicology, Inc., Gainesville, FL, USA.
⁸ Department of Toxicology, University of Wuerzburg, Wuerzburg, Germany.
⁹ Human and Environmental Toxicology, University of Konstanz, Konstanz, Germany.
¹⁰ Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat 'Rovira i Virgili', Reus, Spain.
¹¹ The Health Policy Center, Bethesda, MD, USA.
¹² Technical University of Munich, Hohenbachernstrasse 15-17, D-85350, Freising, Weihenstephan, Germany. Electronic address: helmut.greim@mytum.de.
¹³ McLaughlin Centre for Risk Assessment, University of Ottawa, Ottawa, Canada.
¹⁴ Toxicology, Hamburg, Germany.
¹⁵ Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland.
¹⁶ Nanosafety Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland.
¹⁷ Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.
¹⁸ Department of Chemistry & Pharmaceutical Sciences, Vrije Universiteit, Amsterdam, the Netherlands.

PMID: 32360654
DOI: 10.1016/j.toxlet.2020.04.008

Editorial

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Herman Autrup et al. Toxicol Lett. 2020.

. 2020 Oct 1:331:259-264.

doi: 10.1016/j.toxlet.2020.04.008. Epub 2020 Apr 30.

Authors

Affiliations

¹ Institute of Public Health, University of Aarhus, Aarhus, Denmark.
² College of Pharmacy and Health Sciences, St John's University, Queens, NY, USA.
³ Queen Mary University of London, UK.
⁴ Division of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
⁵ National Heart & Lung Institute, Imperial College, London, UK.
⁶ Leibniz Research Centre for Working Environment and Human Factors (IfADo), TU Dortmund, Dortmund, Germany.
⁷ Applied Pharmacology and Toxicology, Inc., Gainesville, FL, USA.
⁸ Department of Toxicology, University of Wuerzburg, Wuerzburg, Germany.
⁹ Human and Environmental Toxicology, University of Konstanz, Konstanz, Germany.
¹⁰ Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat 'Rovira i Virgili', Reus, Spain.
¹¹ The Health Policy Center, Bethesda, MD, USA.
¹² Technical University of Munich, Hohenbachernstrasse 15-17, D-85350, Freising, Weihenstephan, Germany. Electronic address: helmut.greim@mytum.de.
¹³ McLaughlin Centre for Risk Assessment, University of Ottawa, Ottawa, Canada.
¹⁴ Toxicology, Hamburg, Germany.
¹⁵ Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland.
¹⁶ Nanosafety Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland.
¹⁷ Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.
¹⁸ Department of Chemistry & Pharmaceutical Sciences, Vrije Universiteit, Amsterdam, the Netherlands.

PMID: 32360654
DOI: 10.1016/j.toxlet.2020.04.008

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Affiliations

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Authors

Affiliations

Conflict of interest statement

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources